How does Vortioxetine improve cognition?

Vortioxetine targets the neurotransmitter serotonin, which can affect mood, memory, and other cognitive functions [1]. It appears to improve multiple aspects of cognitive function in people with depression, though evidence for its effects in healthy adults is currently lacking.

Does Trintellix improve cognitive function?

The FOCUS and CONNECT studies showed TRINTELLIX had a positive effect on processing speed, an important aspect of cognitive function that may be impaired in adult patients with acute MDD.

What are the benefits of Vortioxetine?

Vortioxetine is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

Do SSRIs affect cognitive function?

Fluoxetine is a selective serotonin reuptake inhibitor or SSRI, which causes an increase in levels of serotonin in the brain. There are suggestions that SSRIs may impair cognitive function such as thinking, memory and concentration as well as affecting behavioural function.

Does Vortioxetine improve memory?

Acute injection of vortioxetine dose-dependently reversed 5-HT depletion-induced memory deficits in both tests. Chronic p.o. vortioxetine administration significantly improved memory performance only in the NOR. Acute injections of vehicle or vortioxetine at 10 mg/kg 1 hour prior to behavioral test.

Is Vortioxetine better than venlafaxine?

Present review indicates that vortioxetine is as efficacious as venlafaxine XR in the treatment of MDD in acute phase, based on mean changes of MADRS, CGI-S, CGI-I and HAMA, and rate of response and remission. Additionally, its acceptability between the both treatments in such patients was comparable.

What is the mechanism of action of Trintellix?

Trintellix® has a unique multimodal mode of action, which works through a combination of two mechanisms of action: receptor activity modulation and reuptake inhibition. Trintellix® is both an inhibitor of serotonin reuptake, mimics the effects, or blocks the receptors effect at serotonin.

Is Vortioxetine a SNRI?

Vortioxetine received FDA approval for the treatment of major depressive disorder in 2013. The drug is an SSRI, but it also acts as a 5HT agonist, antagonist, and transport inhibitor.

How do SSRIs affect memory?

Our findings show that patients taking SSRIs experienced statistically significant memory loss during 8 weeks of treatment; age and gender did not influence this result. In contrast, Levkovitz et al. and Culang-Reinlieb et al. reported that some SSRIs have improved memory function in patients with depression [17, 18].

Do antidepressants help with cognitive function?

Many studies have reported a positive effect of various antidepressants on cognition. 10,11) Recent comprehensive reviews confirmed that some cognitive symptoms can be improved by antidepressant treatment. 12,13) Numerous studies have reported on the correlates of cognitive function in patients with MDD.

Is Vortioxetine well tolerated?

The drug is generally well tolerated with the most prevalent side effects being mild to moderate nausea along with (mostly transient) headaches. Vortioxetine may significantly improve the quality of life in patients suffering from depression.

Is Effexor SSRI or SNRI?

What you need to know about venlafaxine (Effexor) Venlafaxine, also known as Effexor, is one of the most commonly prescribed antidepressants in the United States. It is a serotonin-norepinephrine reuptake inhibitor (SNRI).