How reliable is CA 15-3?

CA 15-3 in the diagnostic and follow up of patients with breast cancer has a sensitivity ranging from 75-76.9\% and the specificity ranging from 85.5-93\%.

What does an elevated CA 15/3 mean?

Cancer antigen 15-3 (CA15-3) is a protein made by a variety of cells, particularly breast cancer cells. The protein moves into the blood, where it can be measured. CA15-3 levels are higher than normal in most women with breast cancer that has spread to other parts of the body (called metastatic breast cancer).

What is the difference between CA 27/29 and CA 15-3?

Since all breast cancers do not express the CA 27-29 antigen, this assay cannot detect all breast cancers. The CA 15-3 assay can be used instead of the CA 27-29 assay. Although CA 27-29 may be more sensitive for breast cancer, its indications and limitations parallel those of CA 15-3.

What is a CA 15/3 test?

Cancer antigen 15-3 (CA 15-3) is used to monitor response to breast cancer treatment and disease recurrence. The reference range of serum CA 15-3 is less than 30 U/mL. The upper limit of the range varies depending on the laboratory and kit used for the test.

What is a normal CA 15-3?

CA 15-3 is measured in units per milliliter (U/mL). A normal test should be less than or equal to 30 U/mL. It is important to know that having a positive CA 15-3 blood test does not mean you have breast cancer or that your breast cancer has come back. Other conditions can cause CA 15-3 to be in your blood.

What does it mean when tumor markers decrease?

If tumor marker levels go down, it usually means the treatment is working. Help find out if a cancer has spread to other tissues. Help predict the likely outcome or course of your disease. Check to see if your cancer has come back after successful treatment.

What can cause tumor markers to go up?

Tumor marker levels may be higher when there is cancer in the body. They are not very “specific,” meaning non-cancer health issues can also cause these levels to be higher. They must be used along with radiology tests and exams by your healthcare provider.