How do you take TB medicine?

This medicine should be taken on an empty stomach, 1 hour before or 2 hours after a meal, with a full of glass of water. It is important to take this medicine on a regular schedule. If this medicine upsets your stomach, take it with food.

How long is treatment for MDR-TB?

MDR- and XDR-TB need prolonged treatment duration, from 18 to 24 months after sputum culture conversion, as recommended by the World Health Organization (WHO) [2]. A prolonged duration of treatment may lead to poor adherence, higher cost and undue toxicity.

What is the best treatment for MDR-TB?

Among the first group (the oral first-line drugs) high-dose isoniazid, pyrazinamide, and ethambutol are thought of as an adjunct for the treatment of MDR and XDR tuberculosis. The second group is the fluoroquinolones, of which the first choice is high-dose levofloxacin.

Is amikacin used for TB?

The World Health Organization recommends intravenous amikacin for the treatment of MDR-TB at a dose of 15 mg/kg. However, higher doses are associated with significant toxicity.

What are the side effects of MDR-TB treatment?

All patients received standardized therapy for MDR-TB. The major adverse effects included neurologic side effects (depression, convulsions, consciousness, psychosis, suicide; 7.5\%), hepatitis (5\%), rash (1.3\%), renal toxicity (3.8\%), and auditory toxicity (14.5\%).

Why is multiple drug therapy used in treatment of tuberculosis?

When two or more drugs to which in vitro susceptibility has been demonstrated are given together, each helps prevent the emergence of tubercle bacilli resistant to the others.

What are the side effects of amikacin?

Side Effects

• Nausea, vomiting, stomach upset, or loss of appetite may occur.
• Tell your doctor right away if you have any serious side effects, including: numbness/tingling, muscle twitching or weakness, seizure.

Can amikacin be given orally?

Amikacin may be administered once or twice a day and is usually given by the intravenous or intramuscular route, though it can be given via nebulization. There is no oral form available, as amikacin is not absorbed orally.