Is succinylcholine contraindicated in hyperkalemia?

Hyperkalemia (serum potassium >5.5 mEq/L) is often considered a contraindication to succinylcholine (SCh) use, even though the increase in plasma potassium after SCh administration is modest (generally <0.5 mEq/L).

How is it that succinylcholine can cause depolarization but paralysis?

Unlike Ach, succinylcholine produces continuous stimulation of the nicotinic receptor, and the endplate membrane remains depolarized with the channel open. The resulting skeletal muscle paralysis occurs because the hydrolysis of succinylcholine is slow compared with Ach.

What does succinylcholine do to your body?

Succinylcholine is a skeletal muscle relaxant for intravenous (IV) administration indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

What is the mechanism of action of pancuronium?

The risk or severity of Tachycardia can be increased when Arbutamine is combined with Pancuronium. The risk or severity of Tachycardia can be increased when Arformoterol is combined with Pancuronium. Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Pancuronium.

What does succinylcholine do to potassium?

Succinylcholine causes for a transient elevation in potassium by 0.5 – 1.0 mEq in the first 3-5 minutes following administration. This is not of grave concern for most patients as their potassium level is likely normal with hopefully normal kidney function.

Does rocuronium cause hyperkalemia?

Background: Succinylcholine provides rapid onset of neuromuscular blockade and short duration of action, but its administration may be associated with hyperkalemia. Rocuronium is not known to increase potassium concentration, has fast onset of activity, and can be rapidly reversed by sugammadex.

What is the mechanism of action of atracurium?

Atracurium antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.

What are the muscarinic effects of succinylcholine?

Succinylcholine can cause a rapid increase in intraocular pressure due to effects on ocular blood vessels & myofibrils. It can cause cardiac arrhythmias (increase or decrease in heart rate) because of its effects on muscarinic receptors and nicotinic-ganglionic receptors.