What are the types of epitopes?

There are three types of epitope: conformational, linear, and discontinuous. This classification is based upon their structure and their interaction with the antibody’s paratope.

What are the properties of B cell epitopes?

The features of B cell epitope are hydrophilicity, surface accessibility, beta turns, exposed surface, polarity and antigenic properties of amino acids. These properties of polypeptides chains have been correlated with the location of the continuous and discontinuous conformational epitopes.

Do B cells respond to an epitope?

Abstract. Epitopes or antigenic determinants are regions of proteins that can trigger a cellular immune response mediated by T or B cells. B cell epitopes are either peptides or protein surface residues that bind to an antibody.

What are T-cell and B cells?

T cells (thymus cells) and B cells (bone marrow- or bursa-derived cells) are the major cellular components of the adaptive immune response. T cells are involved in cell-mediated immunity, whereas B cells are primarily responsible for humoral immunity (relating to antibodies).

What is the epitope?

epitope, also called antigenic determinant, portion of a foreign protein, or antigen, that is capable of stimulating an immune response. An epitope is the part of the antigen that binds to a specific antigen receptor on the surface of a B cell.

What is the function of an epitope?

What are epitopes and Paratopes?

Epitope refers to the part of an antigen molecule to which an antibody attaches itself, while paratope refers to the part of the molecule of an antibody that binds to an antigen.

Where is the epitope located?

The small site on an antigen to which a complementary antibody may specifically bind is called an epitope or antigenic determinant. This is usually one to six monosaccharides or five to eight amino acid residues on the surface of the antigen.

How many amino acids are in the epitope?

In general, an epitope is approximately five or six amino acids in length. So, a typical full-length protein sequence actually contains many different epitopes against which antibodies can bind. And, for any given protein sequence, one will typically find that multiple unique antibodies will recognize the protein.

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