What does a positive MOG antibody mean?

While the function of this glycoprotein is not exactly known, MOG is a target of the immune system in this disease. The diagnosis is confirmed when MOG antibodies in the blood are found in patients who have repeated inflammatory attacks of the central nervous system.

What is a MOG blood test?

The test uses live cells to identify patients who are positive for an antibody to myelin oligodendrocyte glycoprotein (or “MOG,” for short).

What is myelin oligodendrocyte glycoprotein disease?

Other clinical aspects of MOGAD are reviewed separately. (See “Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Clinical features and diagnosis”.) TREATMENT. Treatment of MOGAD can be stratified by acute attack treatment and attack prevention strategies.

What does MOG disease stand for?

Myelin oligodendrocyte glycoprotein (MOG) is a myelin protein that has long been important in mouse models of demyelinating disease, causing loss or destruction of the protective sheath around nerves.

What are the symptoms of MOG?

Signs & Symptoms

• Loss or blurring of vision in one or both eyes.
• Loss of color vision.
• Paralysis (no motor function) of a limb or limbs.
• Paraparesis (weakness) of a limb or limbs.
• Loss of sensation.
• Loss of bladder or bowel control.
• Profound bladder retention.
• Seizures. 4,9

How long can you live with MOG disease?

NMO is also known as Devic’s disease or neuromyelitis optica spectrum disorder (NMOSD). Patients with neuromyelitis optica (NMO) patients have a 91\% to 98\% five-year survival rate. Current research indicates that neuromyelitis optica (NMO) patients have a 91\% to 98\% five-year survival rate.

What is the life expectancy of someone with MOG?

What is MOG disease symptoms?

Symptoms can include:

• Loss or blurring of vision in one or both eyes.
• Loss of color vision.
• Paralysis (no motor function) of a limb or limbs.
• Paraparesis (weakness) of a limb or limbs.
• Loss of sensation.
• Loss of bladder or bowel control.
• Profound bladder retention.
• Seizures. 4,9

Can a Mog go away?

If you have MOG antibodies you are likely to just have a ‘one-off’ attack and will usually recover well. Some people do experience further attacks, but the risk of this may be reduced if you take a medication called prednisolone for 3-12 months after the original episode.

How is MOG treated?

How is MOG antibody demyelination treated? Intravenous steroid treatment is often used to treat the acute symptoms of demyelination to try to reduce the inflammation that has occurred. This will usually be given at high dose for three to five days via a cannula into a vein.

Is MOG the same as MS?

MOG is a glycoprotein uniquely expressed in oligodendrocytes in the CNS. MOG antibodies were originally thought to be involved in multiple sclerosis (MS), but subsequent studies found it to be a distinct disease.

Is MOG disease curable?

Although it can be treated, it is very devastating and sometimes fatal. It is important to know that exposure to these medications in MOG antibody disease has not led to a known case of PML.