What would happen if the Na K pump was inhibited?

Inhibition of this pump, therefore, causes cellular depolarization resulting not only from changes in Na+ and K+ concentration gradients, but also from the loss of an electrogenic component of the resting membrane potential.

What would happen to a cell if the sodium potassium pump was poisoned?

Explanation: The NaK pump is a specialised transport protein found in the cell membranes. It is responsible for movement of potassium ions into the cell while simultaneously moving sodium ions outside the cell. Thus cell functioning would be drastically affected if due to some reason the NaK pump is destroyed.

How does potassium affect resting membrane potential?

For instance, as potassium levels increase in the extracellular space, the magnitude of the concentration gradient for potassium across the myocyte diminishes, thus decreasing the resting membrane potential (that is, –90 mV to –80 mV; see Fig.

How would the resting membrane potential be affected if ouabain is applied to the cell?

The effect of ouabain on the resting membrane potential, therefore, was due to a change in the transmembrane potassium ion gradient. This, In turn, resulted from a decrease in intracellular potassium activity and, apparently, from an increased potassium activity at the cell surface.

What would occur to the membrane potential of a cell if the sodium-potassium pump was not present in the plasma membrane?

Sodium-potassium pump maintains concentration gradients for these two ions. Action potential could not be initiated (because Na+ crossing cell membrane is necessary for depolarization to occur, which is step one of an action potential), so neurons would cease to function.

What will be the effect on membrane potential if Na+ ions move into the cell quizlet?

***Once the membrane potential reaches threshold, the opening of some voltage-gated Na+ channels allows Na+ ions to rush into the cell. This causes further depolarization of the membrane, which in turn causes more voltage-gated Na+ channels to open.

How does the sodium-potassium pump contribute to membrane potential?

It acts to transport sodium and potassium ions across the cell membrane in a ratio of 3 sodium ions out for every 2 potassium ions brought in. In the process, the pump helps to stabilize membrane potential, and thus is essential in creating the conditions necessary for the firing of action potentials.

What affects resting membrane potential?

The resting membrane potential is determined mainly by two factors: the differences in ion concentration of the intracellular and extracellular fluids and. the relative permeabilities of the plasma membrane to different ion species.

What effect does ouabain have on an action potential?

DOSE-EFFECT RELATIONSHIP It has been shown previously40 that rela- tively high ouabain concentrations (10~7 to 10~8 M/L) lead to progressive and irreversible changes of the resting and action potentials. For instance, with a concentration of 10~8 M/L excitability was irreversibly lost at the end of about 60 minutes.

How does ouabain affect action potential?

Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

What would happen to the resting membrane potential if active transport suddenly stopped working?

It maintains the concentration gradients of Na+ and K+, helping to stabilize resting membrane potential. If stopped working, electrochemical grandient would equalize/disappear and actions potentials could not be generated, so the cell would stop working.