What does the Walker A motif do?

Walker A motif, also known as the Walker loop, or P-loop, or phosphate-binding loop, is a motif in proteins that is associated with phosphate binding. Walker motif A-binding has been shown to cause structural changes in the bound nucleotide, along the line of the induced fit model of enzyme binding.

What is AP Loop NTPase?

P-loop NTPase folds are α-β proteins that contain regularly recurring α-β units with the five β-strands (β1–β5) and characterized by the presence of sequence patterns such as GxxxxGKS/T (where x is any residue), known as a Walker A motif and a Walker B motif (hhhh[D/E], where h is a hydrophobic residue) [4].

Which of the following sequences contains a P-loop consensus sequence?

Sequence alignments of the corresponding structural elements (Fig. S3), reveal that interactions between helix C and one or both of the two N-terminal P-loop amino acids are highly conserved in each of these P-loop NTPases.

What is AP Loop biology?

The P-loop is a fingerprint sequence that characterizes ATP- or GTP-binding proteins and is part of the nucleotide—binding motif (1). The P-loop fingerprint sequence is used to identify ATP- or GTP- binding proteins from their primary structure (1). …

What type of enzyme is Atpase?

ATPases are a group of enzymes that catalyze the hydrolysis of a phosphate bond in adenosine triphosphate (ATP) to form adenosine diphosphate (ADP). They harness the energy released from the breakdown of the phosphate bond and utilize it to perform other cellular reactions.

What are some examples of motif?

Examples of Motif in Narrative Writing

• A repeated reference or visual of shattered glass (something in life is about to break)
• Recurring dishonest characters (to cue up the discovery of an unfaithful spouse)
• A character who constantly misplaces things (as the loss of someone or something significant is on the horizon)

What is a motif and domain?

A motif is a short conserved sequence pattern associated with distinct functions of a protein or DNA. It is often associated with a distinct structural site performing a particular function. A domain is also a conserved sequence pattern, defined as an independent functional and structural unit.

What is a dead box protein?

DEAD box proteins are helicases that perform unwinding in an energy dependent approach and are able to perform these snRNP rearrangements in a quick and efficient manner. There are three DEAD box proteins in the yeast system, Sub2, Prp28, and Prp5, and have been proven to be required for in vivo splicing.

What is ATPase responsible for?

The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. V-ATPase is best known for its acidification of endosomes and lysosomes and is also important for luminal acidification of specialized cells.