What does no monoclonal band detected mean?

If a monoclonal protein is identified, its immunoglobulin class (IgG, IgA, IgM, IgD, IgE) and light chain type (kappa, lambda) are determined by immunofixation. If no monoclonal protein is detected, further testing is not warranted.

Does multiple myeloma always show up in blood tests?

Blood work might reveal the abnormal cells that myeloma produces, including M proteins and beta-2-microglobulin. The type of proteins found in the blood can also confirm the aggressiveness of the myeloma. In addition, doctors can use blood work to check for blood cell counts, kidney function, and calcium levels.

Can you have multiple myeloma without M spike?

Non-secretory Myeloma Some people with multiple myeloma don’t make enough M proteins or light chains for tests to show they have it. This is called non-secretory myeloma. A bone marrow biopsy can help diagnose this type of myeloma.

What does no monoclonal protein detected?

A small number of patients with myeloma have either “oligosecretory disease,” in which the detectable level of monoclonal protein is low, or “nonsecretory disease,” in which no monoclonal protein can be detected.

Can Myeloma be misdiagnosed?

Since multiple myeloma symptoms can be mistaken for other ailments, and in some cases, symptoms may not be present at all, it’s important to know the warning signs and what can put you at risk of developing the disease.

What is monoclonal band?

Monoclonal gammopathy is the name given to a “band” in serum protein electrophoresis, caused by the overproduction of a population of plasma cells, which in turn produce a single immunoglobulin (the so-called “plasma cell dyscrasias”).

What does abnormal protein band mean?

When an abnormal band on either a serum or a urine electrophoresis pattern suggests the presence of a single type of immunoglobulin (monoclonal), immunofixation electrophoresis (IFE) or immunosubtraction electrophoresis can be used as follow-up tests to further identify abnormal proteins.

What happens if you dont treat multiple myeloma?

If left untreated, excess amounts of myeloma protein can cause kidney damage or even renal failure. A kidney biopsy might be performed to determine the exact cause of the kidney damage.