How do you administer BeneFIX?

BeneFIX is administered by intravenous infusion after reconstitution of the lyophilised powder for solution for injection with sterile 0.234\% sodium chloride solution (see section 6.6). BeneFIX should be administered at a slow infusion rate. In most of the cases, an infusion rate of up to 4 mL per minute has been used.

What is the cost of BeneFIX?

The lowest GoodRx price for the most common version of Benefix is around $4,236.30, 63\% off the average retail price of $11,655.05. Compare coagulation factors.

How is Factor 9 activated?

The coagulation protease factor IX is activated during hemostasis by the factor VIIa/tissue factor complex and by factor XIa.

What company makes BeneFIX?

for Health Care Professionals: BENEFIX U.S. Physician Prescribing Information. BENEFIX U.S. Medical Information Page – clinical & safety information, ways to contact Pfizer Medical & other resources.

What is the generic name for BeneFIX?

Generic Name: coagulation factor IX (recomb) This medication is used to prevent or control bleeding in people with little or no factor IX (due to hemophilia B, Christmas disease). Factor IX is a protein (clotting factor) in the blood that works with other clotting factors to help the blood clot and stop bleeding.

What is the half life of BeneFIX?

The pharmacokinetic characteristics of BeneFIX were also assessed in 23 of these patients. The mean increase in circulating FIX activity was 0.72 IU/dL per IU/kg infused (range 0.39, 1.24) and the mean plasma FIX half-life 22 h (range 13, 35).

Is hemophilia expensive to treat?

The cost of drug therapy for a person with hemophilia can be several hundred thousand dollars per year and annual treatment costs of $1 million or more are not unheard of for patients with the most severe forms of the disease.

How expensive is it to treat hemophilia?

Treatment for hemophilia is extremely expensive. This is a lifetime expense. The average cost is $40,000 to $50,000 a year. Complications from hemophilia can bring further expenses, which may be over $100,000.

What disease is called Christmas?

Hemophilia B, also known as factor IX deficiency or Christmas disease, is the second most common type of hemophilia. The disorder was first reported in the medical literature in 1952 in a patient with the name of Stephen Christmas.

Why is it called Christmas disease?

Hemophilia B is also known as Christmas disease. It is named after the first person to be diagnosed with the disorder in 1952, Stephen Christmas. As the second most common type of hemophilia, it occurs in about 1 in 25,000 male births and affects about 4,000 individuals in the United States.

What is BeneFIX made of?

BeneFIX is not derived from human blood. It is produced by a genetically engineered Chinese hamster ovary (CHO) cell line that is extensively characterized. No additives of animal or human origin are used during the cell culture, purification, and formulation processes of BeneFIX.

How do you administer IX Factor?

Factor IX is generally administered as a slow IV push (bolus injection). Continuous infusion of Factor IX is indicated for patients requiring admission for severe bleeds or surgical procedures. Factor IX replacement for such patients should be managed in consultation with Clinical Haematology.

What is biobenefix used to treat?

BeneFIX is a recombinant human blood coagulation factor IX indicated for the treatment of: Adults and children with hemophilia B (congenital factor IX deficiency or Christmas disease) for: On-demand treatment and control of bleeding episodes. Perioperative management of bleeding.

What is Benef IX used to treat?

BeneF ix, Coagulation Factor IX (Recombinant), is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital factor IX deficiency or Christmas disease. BeneF ix is NOT used to treat hemophilia A.

What is the generic name for Benefix?

BeneFIX. Generic Name: coagulation factor IX (koe AG yoo LAY shun FAK tor NINE) Brand Name: AlphaNine SD, Alprolix, BeneFIX, Idelvion, Ixinity, Mononine, Rebinyn, Rixubis. Medically reviewed by Drugs.com on April 5, 2021. Written by Cerner Multum.

Can BenefiX be used intravenously after reconstitution?

For Intravenous Use after Reconstitution Treatment with BeneFIX, Coagulation Factor IX (Recombinant), should be initiated under the supervision of a physician experienced in the treatment of hemophilia B. Each vial of BeneFIX has the rFIX potency in the International Units (IU) stated on the vial.