Is HERDA dominant or recessive?

HERDA has an autosomal recessive mode of inheritance and affects stallions and mares in equal proportions. Research carried out in Dr. Danika Bannasch’s laboratory at the University of California, Davis, identified the mutation causing HERDA. HERDA is caused by a single base change in the gene PPIB (c.

Where did HERDA come from?

Hereditary equine regional dermal asthenia (HERDA), also known as hyperelastosis cutis (HC), is an inherited autosomal recessive connective tissue disorder. It develops from a homozygous recessive mutation that weakens collagen fibers that allow the skin of the animal to stay connected to the rest of the animal.

What is a HERDA carrier in horses?

HERDA is an inherited (autosomal recessive) skin disease in Quarter Horses and related breeds. It causes skin lesions along the back (often under the saddle area) of affected horses. A DNA test is available to confirm diagnosis of affected animals and identify carriers.

What is Hyperelastosis cutis?

Hyperelastosis cutis is an inherited autosomal recessive connective tissue disorder. Affected horses are characterized by hyperextensible skin, scarring, and severe lesions along the back. The disorder is caused by a mutation in cyclophilin B.

Is HERDA simply inherited?

Hereditary equine regional dermal asthenia (HERDA), also known as hyperelastosis cutis (HC), is an inherited connective tissue disorder.

Why does HERDA lead to skin lesions?

The predominance of skin lesions have been shown to occur on the dorsum of HERDA-affected horses. While this has been postulated to be due to increased exposure to sunlight of these areas, the precise pathological mechanism which causes this to occur is unclear.

What is the 5 panel test for horses?

The Five-Panel Genetic Test These include hyperkalemic periodic paralysis (HYPP), polysaccharide storage myopathy (PSSM), glycogen branching enzyme disease (GBED), hereditary equine regional dermal asthenia (HERDA), and malignant hyperthermia (MH).

What is horse GBED?

Glycogen branching enzyme deficiency (GBED) is a disorder first recognized by clinicians at the University of Minnesota that causes muscle weakness in Quarter Horse and related breeds. The clinical presentation of this disease is variable. Late term abortion or stillbirth is described for GBED.

What is PSSM1 in horses?

Polysaccharide storage myopathy (PSSM1) is characterized by the abnormal accumulation of the normal form of sugar stored in muscle (glycogen) as well as an abnormal form of sugar (amylase-resistant polysaccharide) in muscle tissue. By definition horses with PSSM1 have a distinctive genetic mutation in the gene.

What Quarter Horse bloodlines carry GBED?

Additionally, she reported that all the known affected foals and carriers of GBED are descendants of the Quarter Horse sire Zantanon and his son King, and about 8\% of King descendants are carriers of GBED.

What Quarter Horse bloodlines carry PSSM?

PSSM1 is a glycogen storage disease that has been found in over 20 different breeds. It was first recognized in horses with Quarter Horse bloodlines such as Quarter Horses, American Paint Horses and Appaloosas and in draft and warmblood breeds with continental European bloodlines (Belgian and Percheron, for example).

What does Herda stand for?

Phenotype: Hereditary equine regional dermal asthenia (HERDA) is an inherited skin disease characterized by hyperextensible skin, scarring, and severe lesions along the back of affected horses. Alleles: N = Normal/Unaffected, HRD = Hereditary equine regional dermal asthenia

What is Herda disease in horses?

Hereditary equine regional dermal asthenia (HERDA) is caused by a G to A substitution at base 115 of the gene for peptidyl-prolyl isomerase B (PPIB), causing a glycine to arginine substitution at amino acid position 39 in the PPIB protein (PPIB-G39R).

Is Herda a dominant or recessive gene?

HERDA has an autosomal recessive mode of inheritance and affects stallions and mares in equal proportions. Research carried out in Dr. Danika Bannasch’s laboratory at the University of California, Davis, identified the mutation causing HERDA. HERDA is caused by a single base change in the gene PPIB (c.115G>A).

How many copies of the HERDA gene do horses have?

Normal. Horse does not have the HERDA gene. Carrier. Horse carries 1 copy of the HERDA gene. Affected. Horse has 2 copies of the HERDA gene.