How does Atgam work for aplastic anemia?

ATG works by killing specific cells in your immune system called T-lymphocytes — the cells that are attacking bone marrow stem cells in aplastic anemia. This allows an aplastic anemia patient’s bone marrow to rebuild its supply of bone marrow stem cells, causing blood counts to go up.

What is Atgam drug?

Atgam is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Atgam is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.

Is Atgam hazardous?

Inform patients that Atgam may cause serious allergic reactions, infection or abnormal liver or renal function. Advise the patient to discontinue Atgam and seek immediate medical attention if any signs/symptoms of an allergic or immune reaction occur [see Warnings and Precautions (5.1)].

What is horse anti-thymocyte globulin?

ANTI-THYMOCYTE IMMUNE GLOBULIN (an tee THI mo cite im MUNE GLOB yoo lin) weakens the body’s immune system. This medicine is used to prevent and to treat kidney transplant rejection. It is also used to treat aplastic anemia.

How is Atgam administered?

ATGAM is appropriately administered into a vascular shunt, arterial venous fistula, or a high-flow central vein through an in-line filter with a pore size of 0.2 to 1.0 micron.

How do you infuse Atgam?

Dilute ATGAM for intravenous infusion in an inverted bottle of sterile vehicle so the undiluted ATGAM does not contact the air inside. Add the total daily dose of ATGAM to the sterile vehicle (see Compatibility and Stability). Do not exceed a concentration of 4 mg of ATGAM per mL.

How much does Atgam cost?

Atgam 50 MG/ML discount prices at U.S. pharmacies start at $453.90 per ampul for 1 ampuls.

How do you administer an Atgam?

Administer the first dose within 24 hours before or after the transplant. Treatment of Rejection: The first dose of ATGAM can be delayed until the diagnosis of the first rejection episode. The recommended dose is 10 to 15 mg/kg daily for 14 days. Additional alternate-day therapy up to a total of 21 doses can be given.

What does USP 800 promote?

USP General Chapter <800> provides standards for safe handling of hazardous drugs to minimize the risk of exposure to healthcare personnel, patients and the environment.

How much does Antithymocyte globulin cost?

The costs for basiliximab and antithymocyte globulin were calculated based on average wholesale prices (AWP). The price of basiliximab was $1224 per dose and the price of antithymocyte globulin was $262.24 per 250 mg ampoule [9].

How do you treat aplastic anemia?

The options are an UD BMT, a second course of IST (ATG+CsA), or an alternative donor transplant (Alt Donor Tx, indicating haploidentical transplants or cord blood [CB] transplants). At older than 60 years of age, medical treatment is preferable over BMT.

How is Antithymocyte globulin given?

Background. Antithymocyte globulin is a hyperimmune globulin preparation made from plasma of rabbits or horses that have been immunized with human thymocytes or T cells. ATG is given by infusion only and leads to a rapid decrease in circulating T cells.

What is Atgam used for in the body?

Indication: What Atgam is used for. Atgam belongs to a group of medicines called immunosuppressants (anti-rejection medicines). Atgam is used in patients who are having a kidney transplant. It helps to stop your body’s immune system from rejecting the new kidney. Your doctor may prescribe Atgam for another purpose.

Does Atgam need to be refrigerated?

ATGAM Sterile Solution, containing 50 mg/mL lymphocyte immune globulin, anti-thymocyte globulin [equine], is supplied as follows: Store in a refrigerator at 2° to 8°C (36° to 46°F). DO NOT FREEZE.

What is Atgam sterile solution for horses?

ATGAM Sterile Solution contains lymphocyte immune globulin, anti-thymocyte globulin [equine]. It is the purified, concentrated, and sterile gamma globulin, primarily monomeric IgG, from hyperimmune serum of horses immunized with human thymus lymphocytes.

Can Atgam cause anaphylaxis?

Although ATGAM is processed to reduce the level of antibodies that will react to non-T cells, physicians should be prepared for the potential risk of anaphylaxis and monitor patients for signs and symptoms during infusion. ATGAM Sterile Solution contains lymphocyte immune globulin, anti-thymocyte globulin [equine].