What is clonidine usually used for?

Clonidine is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.

How do you administer clonidine injection?

4.2 Dose and method of administration Subcutaneous or intramuscular injection of Clonidine HCl Injection should only be administered to patients in a lying position. A dosage of 0.2 mcg/kg/minute is recommended for i.v. infusion.

What is clonidine used for in ICU?

The drug is licensed for the treatment of hypertension, migraine and menopausal flushing. It is also an analgesic, sedative and anxiolytic. These properties along with its ability to maintain peri-operative haemodynamic stability make clonidine a useful agent in anaesthesia and intensive care.

How long does clonidine high last?

Peak plasma clonidine levels are attained in approximately 1 to 3 hours. Following intravenous administration, clonidine displays biphasic disposition with a distribution half-life of about 20 minutes and an elimination half-life ranging from 12 to 16 hours.

Can clonidine make you feel high?

Clonidine can make some people feel sleepy or relaxed, but it doesn’t typically make you feel “high.” However, some people may misuse clonidine by taking it with other drugs or alcohol to intensify their effects and create a “high” feeling.

Can clonidine be crushed?

Swallow the extended-release tablet whole. Do not cut, crush, or chew it. You may take the tablet with or without food. Clonidine extended-release tablets works differently than clonidine immediate-release tablets.

Can Clonidine be given IV?

Clonidine in continuous intravenous infusion is a good drug for use as a sedative or for the treatment of withdrawal syndrome. In addition, it significantly reduces other sedative drugs which could have important adverse effects.

Is Clonidine a controlled substance?

Clonidine isn’t a controlled substance, and it doesn’t have much street value. Doctors are often more willing to write a prescription for clonidine because its abuse potential isn’t high.

Why is clonidine so sedating?

It has been postulated that clonidine exerts its sedative effects via stimulation of the pre-synaptic alpha-2 adrenoceptors of the locus coeruleus, decreasing norepinephrine release [22]. Clonidine also has action on the cholinergic, purinergic, and serotonergic pathways, resulting in analgesia [22].

Is it possible to overdose on clonidine?

What happens if I take too much clonidine? – Clonidine can cause an unsafe drop in blood pressure or heart rate when too much is taken. In overdose it can also cause deep sedation and affect the ability to breathe normally.

Can you crush clonidine?

Do not cut, crush, or chew it. You may take the tablet with or without food. Clonidine extended-release tablets works differently than clonidine immediate-release tablets.

Can Clonidine be crushed?