What is fibrosis of the liver caused from?

Liver fibrosis occurs after a person experiences injury or inflammation in the liver. The liver’s cells stimulate wound healing. During this wound healing, excess proteins such as collagen and glycoproteins build up in the liver.

What does Nafld stand for?

Health care providers divide fatty liver disease into two types. If you just have fat but no damage to your liver, the disease is called nonalcoholic fatty liver disease (NAFLD). If you have fat in your liver plus signs of inflammation and liver cell damage, the disease is called nonalcoholic steatohepatitis (NASH).

How does fatty liver lead to fibrosis?

FLD can progress to a condition called steatohepatitis when the accumulation of fat in the liver causes inflammation, cell death, and scarring. Long-standing steatohepatitis leads to liver fibrosis as scar tissue builds up and replaces healthy liver tissue.

What is the most common cause of fatty liver?

People tend to develop fatty liver if they have certain other conditions, such as obesity, diabetes or high triglycerides. Alcohol abuse, rapid weight loss and malnutrition may also lead to fatty liver. However, some people develop fatty liver even if they have none of these conditions.

How is fibrosis formed?

Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury.

How is NAFLD diagnosed?

Three major types of tests are used to diagnose NAFLD: (1) blood tests such as liver function tests that measure inflammation of the liver; (2) tests to visualize the appearance of the liver, such as ultrasound, computed tomographic (CT) scan, and magnetic resonance imaging (MRI); and (3) newer tests that quantify the …

What is the main cause of Nash?

NAFLD and NASH are both linked to the following: Overweight or obesity. Insulin resistance, in which your cells don’t take up sugar in response to the hormone insulin. High blood sugar (hyperglycemia), indicating prediabetes or type 2 diabetes.

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