What is CD11c a marker for?

CD11c is a widely established marker for dendritic cells (see CD11c protein and function). It can be employed to determine the subsets of dendritic cells (DC) in the immune system (see CD11c expression in human and murine immune system), but CD11c may be more than a marker for DC cells (see CD11c and inflammation).

What are CD11c cells?

CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4.

What is a tolerogenic immune response?

Tolerogenic therapy aims to induce immune tolerance where there is pathological or undesirable activation of the normal immune response. Research using animal models in transplantation and autoimmune diseases has led to early-phase human trials of tolerogenic therapy for autoimmune conditions like Type 1 Diabetes.

What are tolerogenic dendritic cells?

Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens. For that reason, tolerogenic DCs are an important promising therapeutic tool.

What is F4 80 cells?

F4/80 antigen is a mature mouse cell surface glycoprotein expressed at high levels on various macrophages including: Kupffer cells, splenic red pulp macrophages, microglia, gut lamina propria, and Langerhans cells in the skin.

What is F4 80 a marker for?

The F4/80 molecule was established as a unique marker of murine macrophages when a monoclonal antibody was found to recognize an antigen exclusively expressed by these cells.

Do lymphocytes express CD11c?

CD11c is definitely expressed by lymphocytes. Check out the data browser at www.immgen.org for specifics (the gene name for CD11c is itgax) – but it’s now well described that CD11c is expressed by NK cells, activated T cells, a subset of regulatory CD8+ T cells, gdT cells, and certain macrophage populations.

What is a tolerogenic antigen?

Tolerogenic antigen-presenting cells (APCs) are attractive agents for the treatment of autoimmune and inflammatory diseases that are mediated, at least in part, by antigen-specific autoreactive T cells.

What is tolerogenic cell death?

The tolerogenic effect of cell death depends on many factors, including the absence of T cell help, the location of the dying cells (which in part dictates their engulfment by distinct dendritic cell (DC) subtypes), the maturation state of the DC, the production of immunosuppressive factors (such as transforming growth …

What is tolerogenic antigen?

Do eosinophils express F4 80?

Monocytes are F4/80low and most of the monocyte-derived macrophages are F4/80low. Eosinophils express F4/80 as well (though less than macrophages).

What cells express f480?

F4/80 is highly and constitutively expressed on most resident tissue macrophages, including the red pulp macrophages in the spleen, microglia in the brain, Kupffer’s cells in the liver, and Langerhans’ cells in the skin (6).