Does JGA produce renin?

The main components of the JGA are the macula densa of the thick ascending limb, the renin-producing granular cells of the afferent arteriole, and the extraglomerular mesangial cell (Goormaghtigh cell, lacis cell; Figure 47.3).

What activates JGA release renin?

Renin secretion and synthesis are essentially triggered by sympathetic nerve activity with noradrenaline as the main stimulatory transmitter acting via β1 receptors on JGE cells.

How does JGA regulate kidney function?

Regulation involving Juxtaglomerular Apparatus: In kidneys, the JGA acts as a Multi Hormonal renin angiotensin aldosterone system (RAAS). When the glomerular blood flow decreases JG cells activates and releases renin. Renin converts angiotensin in blood to angiotensin 1 and further to angiotensin 2.

Do granular cells release renin?

Granular cells at the end of the afferent arteriole synthesize and release renin by a process regulated by local changes in arteriolar hydrostatic pressure and stretch, and β-adrenoceptor stimulation by norepinephrine released from perivascular sympathetic nerve terminals [86, 97–99].

What is the function of JGA?

The juxtaglomerular apparatus (JGA), consisting of the glomerular afferent and efferent arterioles and the specialized tubular epithelial cells called the macula densa, plays a central role in the regulation of glomerular hemodynamics and renin release.

How JGA is formed?

The juxtaglomerular apparatus is a specialized structure formed by the distal convoluted tubule and the glomerular afferent arteriole. It is located near the vascular pole of the glomerulus and its main function is to regulate blood pressure and the filtration rate of the glomerulus.

What triggers JG cells to release renin?

Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells.

What stimulates the secretion of renin?

Renin is a proteolytic enzyme that is released into the circulation by the kidneys. Its release is stimulated by: sympathetic nerve activation (acting through β1-adrenoceptors) renal artery hypotension (caused by systemic hypotension or renal artery stenosis)

Why is JGA important?

What is JGA explain?

juxtaglomerular apparatus (JGA) A region of tissue found in each nephron in the kidney that is important is regulating blood pressure and body fluid and electrolytes. The JGA also includes chemoreceptor cells of the adjacent region of the distal tubule, which form a tightly packed array called the macula densa.

What triggers granular cells to release renin?

The juxtaglomerular cell is a cell that is located near the glomerulus, hence its name. Similar to cardiac tissue, juxtaglomerular cells harbor β1 adrenergic receptors. When stimulated by epinephrine or norepinephrine, these receptors induce the secretion of renin.

What cells release renin?

juxtaglomerular cells
The main source of renin is the juxtaglomerular cells (JGCs), which release renin from storage granules. Besides the renin-angiotensin system (RAS) in the JGCs, there exist local RASs in various tissues.