What do you mean by Hoogsteen base pairing?

Definition. A Hoogsteen Pair is a non-canonical/non-Watson-Crick hydrogen-bonded motif observed in nucleic acids. Two nucleosides from two different nucleic strands, or from distal regions of the same strand, can be held together by Hoogsteen base pairing.

What is complementary base pairing simple definition?

”’complementary base pairing. The standard arrangement of bases in nucleotides in relation to their opposite pairing, such as thymine being paired with adenine and cytosine paired with guanine.

What do you mean by non-canonical base pairing in DNA?

Description: Non-canonical base pairs are planar hydrogen bonded pairs of nucleobases, having hydrogen bonding patterns which differ from the patterns observed in Watson-Crick base pairs, as in the classic double helical DNA.

Where is Hoogsteen base pairing?

The Hoogsteen base pair, consisting of a syn adenine base paired with an anti thymine base, is found in the 2.1 Å resolution structure of the MATα2 homeodomain bound to DNA in a region where a specifically and a non-specifically bound homeodomain contact overlapping sites.

What is Hoogsteen edge?

Like the purine, there is the Watson-Crick edge(WC) and the Sugar edge(S) but the third edge is referred to as the “C-H” edge(H) on the pyrimidine bases. This C-H edge is sometimes also referred to as the Hoogsteen edge for simplicity. The various edges for the purine and pyrimidine bases are shown in Figure 2.

What is the difference between Watson Crick base pairing and Hoogsteen base pairing?

In Hoogsteen base pairing, the purine base takes a different conformation with respect to pyrimidine base. So, this is the key difference between Watson and Crick and Hoogsteen base pairing. Moreover, Watson and Crick base pairs stabilize the DNA double helix while Hoogsteen base pairs make the helix unstable.

What is meant by complementary base pairing and why is it important?

Function. Complementary base pairing is important in DNA as it allows the base pairs to be arranged in the most energetically favourable way; it is essential in forming the helical structure of DNA. It is also important in replication as it allows semiconservative replication.

What is hoogsteen edge?

What is non canonical?

Definition of noncanonical : not relating to, part of, or sanctioned by a canon : not canonical noncanonical literary works.

What is the difference between Watson-Crick base pairing and Hoogsteen base pairing?

https://www.youtube.com/watch?v=yeNcmwxoMSM