What is the difference between mhc1 and mhc2 presentation?

MHC I glycoproteins are present in all nucleated cells. MHC II glycoproteins are only present on specialised antigen-presenting cells (APCs), including macrophages that engulf foreign particles such as bacteria, dendritic cells that present antigen to T cells, and B cells that produce antibodies.

What is the difference between HLA and MHC?

“The main difference between the two groups is that MHC is often found in vertebrates, while HLA is only found in humans. To simplify, HLA is the human body’s version of MHC. Part of the responsibility of these antigens is to detect cells entering the body.

What defines an endogenous antigen?

Endogenous antigens are antigens found within the cytosol of human cells such as viral proteins, proteins from intracellular bacteria, and tumor antigens. Exogenous antigens are antigens that enter from outside the body, such as bacteria, fungi, protozoa, and free viruses.

What is the difference between processing of endogenous antigens and processing exogenous antigens?

The key difference between endogenous and exogenous antigens is that the endogenous antigens generate within the cells while the exogenous antigens come from the outside of the body. Hence, endogenous antigens are intracellular while exogenous antigens are extracellular.

What do MHC Class 2 molecules do?

The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.

What are the different HLA types?

There are three general groups of HLA, they are HLA-A,HLA-B and HLA-DR. There are many different specific HLA proteins within each of these three groups.

Where are class I HLA found?

The HLA system is located on the short arm of chromosome 6 on band 6p21. 3. This gene system is the largest cluster in the human genome, and it is divided into three main sub-regions: the genes of class I, class II, and class III, which are all involved in immune response and suppression (3) (Figure 1).