Which lipoprotein is most associated with a high risk of heart disease?

LDL (low-density lipoprotein), sometimes called “bad” cholesterol, makes up most of your body’s cholesterol. High levels of LDL cholesterol raise your risk for heart disease and stroke.

What causes lipoprotein A to be high?

Besides genetics, Lipoprotein (a) levels may result from increased intake of some types of fats, and some medical conditions. Treatment of elevated Lipoprotein (a) is based on a person’s risk of heart attack or stroke.

What is a high lipoprotein A level?

A high lipoprotein (a) level may mean you are at risk for heart disease. There are no specific treatments to lower lipoprotein (a). Your level of lipoprotein (a) is determined by your genes and is not affected by your lifestyle or by most medicines.

How does lipoprotein a cause heart disease?

Made in your liver and then entering your bloodstream, lipoprotein(a) has been shown to build up under the inner lining of arteries. This buildup may contribute to the development of atherosclerosis—the formation of fatty plaques in your arteries that can lead to heart disease, heart attack, and stroke.

Why does high lipoprotein cause coronary heart disease?

Some studies showed that Lp(a) particles are prone to oxidation and that the increased risk of coronary artery disease associated with elevated Lp(a) levels may be related in part to their oxidative modification and uptake by macrophages, resulting in the formation of macrophage-derived foam cells [31].

Which lipoprotein is directly related to heart disease?

Population studies have demonstrated that elevated levels of LDL cholesterol and apolipoprotein B (apoB) 100, the main structural protein of LDL, are directly associated with risk for atherosclerotic cardiovascular events (ASCVE).

Does high LPA cause high LDL?

Because it is an inherited condition, people with high Lp(a) can have early heart attacks in their families. There can be enough cholesterol carried on the Lp(a) particles to cause high cholesterol to increase to levels of LDL cholesterol seen in FH.

Can vitamin C lower lipoprotein A?

Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials.

Is lipoprotein a risk factor?

1. Lp(a) is an important but underappreciated risk factor for heart disease. While most people know that low-density lipoprotein (LDL)-C, or bad cholesterol, can cause heart disease, relatively few people know about the risk posed by lipoprotein(a), or Lp(a).

What is the relationship between blood lipoprotein levels and risk of cardiovascular disease?

The robust and specific association between elevated Lp(a) levels and increased cardiovascular disease (CVD)/coronary heart disease (CHD) risk, together with recent genetic findings, indicates that elevated Lp(a), like elevated LDL-cholesterol, is causally related to premature CVD/CHD.