Can hydroquinone make melasma worse?

Treatment. Hydroquinone may be helpful in epidermal-type melasma. Concentrations vary from 2\% to 10\% and hydroquinone may be used twice daily for 12 weeks. Hydroquinone may cause local skin irritation, however, and thereby leading to post-inflammatory hyperpigmentation, making the skin pigmentation worse.

Does pigmentation come back after hydroquinone?

Excessive hydroquinone concentrations may induce toxic or shocking effects on melanocytes, forcing them to regroup and increase their melanin production (resulting in rebound hyperpigmentation).

Does melasma come back after hydroquinone?

ANSWER: The skin condition melasma can be challenging to get rid of completely, and as a chronic condition, it can come back after treatment. With the treatment you mention, intense-pulsed light or IPL, melasma often reappears quickly.

How long does it take for hydroquinone to work on melasma?

By controlling these melanocytes, your skin will become more evenly toned over time. It takes about four weeks on average for the ingredient to take effect. It may take several months of consistent use before you see full results.

How can I permanently remove melasma from my face?

Doctors often use hydroquinone as the first line of treatment for melasma. Hydroquinone is available as a lotion, cream, or gel. A person can apply the hydroquinone product directly to the patches of skin that are discolored. Hydroquinone is available over the counter, but a doctor can also prescribe stronger creams.

How long does melasma take to fade?

Azelaic acid: This cream, lotion or gel is applied twice a day. It’s safe for pregnant women to use. Cysteamine: A small study of 50 people found cysteamine cream to be more effective than a placebo. Hydrocortisone (a topical corticosteroid): Hydrocortisone helps fade the color caused by melasma.

What happens if you use hydroquinone too long?

Chronic adverse events related to exposure to hydroquinone are of greater concern. These complications include ochronosis, nail discoloration, conjunctival melanosis, and corneal degeneration. Ochronosis is the most common chronic complication related to long-term use of hydroquinone.

How do I permanently get rid of melasma?

Hydroquinone: This medication is a common first treatment for melasma. Tretinoin and corticosteroids: To enhance skin lightening, your dermatologist may prescribe a second medicine. Other topical (applied to the skin) medicines: Your dermatologist may prescribe azelaic acid or kojic acid to help reduce melasma.