Can methadone and phenobarbital be taken together?

Interactions between your drugs Using methadone together with other medications that cause central nervous system depression such as PHENobarbital can lead to serious side effects including respiratory distress, coma, and even death.

What drugs interact badly with methadone?

Key Messages

Medicine Classification	Examples	Effect
Anticonvulsants	carbamazepine, phenobarbitone, phenytoin	Reduced methadone levels
Antibiotics	rifampicin
Non-Nucleoside Reverse -Transcriptase Inhibitors	efavirenz, nevirapine
Azole antifungals	fluconazole, ketoconazole	Increased methadone levels

What is contraindicated with methadone?

Other contraindications identified by the manufacturers of methadone include severe respiratory depression, acute asthma, acute alcoholism, head injury and raised intracranial pressure, ulcerative colitis, biliary and renal tract spasm, and patients receiving monoamine oxidase inhibitors or within 14 days of stopping …

Can you take Keflex with methadone?

Drug and food interactions Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Orange juice is not expected to interact.

Can you take Cipro with methadone?

When methadone levels are too high, side effects can occur including drowsiness, confusion, low blood pressure and slowed breathing. Doctors in Sweden have recently reported an interaction between the antibiotic Cipro (ciprofloxacin) and methadone in one of their patients.

Can I take clindamycin with methadone?

No interactions were found between clindamycin and methadone. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Does grapefruit enhance methadone?

Various studies demonstrate that through CYP3A4 inhibition, grapefruit juice increases serum levels of opioids, such as methadone, though no clinically significant effects have been reported. Conclusions: Grapefruit juice inhibits the metabolism of methadone, raising its serum levels.

How much does grapefruit increase methadone?

Grapefruit juice led to a mean 17\% increase in the area under the curve extrapolated to 24 hours for both enantiomers of methadone (range, 3\% to 29\% [P <.

Does methadone interfere with antibiotics?

Methadone has its own antibacterial effect, although at supraphysiological concentrations, and is even synergistic with antimicrobial agents against some organisms. Thus, methadone does not interfere with the antibacterial effects of antibiotics in vitro.

Can you take Cipro and methadone together?

Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression.