How do you reduce lipoprotein LPA?

The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials.

Is it possible to lower lipoprotein A?

Your genes control how much Lp(a) your body makes. Although healthy eating and exercise can help reduce LDL cholesterol, there’s no evidence that a healthier lifestyle can lower Lp(a). Your Lp(a) level is currently thought to be dictated almost entirely by the genes you inherit.

How can I lower my lipoprotein A levels naturally?

Several studies have found that eating pecans, almonds, and walnuts may also help reduce Lp(a) levels [93, 94, 95]. On the other hand, you should avoid low-fat (<20\% of calories) high-carbohydrate diets. Several studies found that these diets increased Lp(a) levels [96, 97, 98].

What causes lipoprotein A to increase?

Besides genetics, Lipoprotein (a) levels may result from increased intake of some types of fats, and some medical conditions. Treatment of elevated Lipoprotein (a) is based on a person’s risk of heart attack or stroke.

Does niacin reduce LPA?

Finally, there is niacin, which can lower lipoprotein(a) ≤30\%, in addition to its salutary effects on LDL cholesterol and HDL cholesterol. Niacin has been shown to downregulate the transcriptional activity of the LPA promoter13 and may also impact the production of apoB100 present in lipoprotein(a).

Is lipoprotein A genetic?

Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein that is under strong genetic control by the LPA gene locus. Genetic variants including a highly polymorphic copy number variation of the so called kringle IV repeats at this locus have a pronounced influence on Lp(a) concentrations.

What is considered high LPA?

In the US guidelines, elevated Lp(a)—defined as ≥ 50 mg/dL or ≥ 125 nmol/L—is considered a “risk-enhancing” factor that can be used to determine how aggressively to treat LDL cholesterol levels.

Does aspirin lower lipoprotein A?

Results: Aspirin lowered serum Lp(a) concentrations to approximately 80\% of the baseline values in patients with high Lp(a) concentrations (>300 mg/L). The percentage of decrease in serum Lp(a) was larger in patients with high Lp(a) than in patients with low Lp(a) (<300 mg/L), irrespective of apo(a) isoform size.

How do I get my lipoproteins back to normal?

These may include medicines or lifestyle changes such as:

1. Eating a healthy diet.
2. Weight Control.
3. Quitting smoking.
4. Getting regular exercise.
5. Reducing stress.
6. Lowering blood pressure.
7. Reducing LDL cholesterol.