Is Antp a Hox gene?

Antennapedia (abbreviated Antp) is a Hox gene first discovered in Drosophila which controls the formation of legs during development. Loss-of-function mutations in the regulatory region of this gene result in the development of the second leg pair into ectopic antennae.

Where is Antennapedia expressed?

thoracic embryonic epidermis
In Drosophila melanogaster, the homeotic Antennapedia (Antp) gene is expressed in the thoracic embryonic epidermis and is required for proper development of the thorax and legs (Abbott and Kaufman, 1986; Carroll et al., 1986; Wirz et al., 1986).

Does antp exist?

Antp is the last gene of the Antennapedia Complex (ANTP-C), that is, the most distal from the centromere, and the one expressed in the most posterior locale.

Is antennapedia dominant or recessive?

Most of the early mutations were dominant – ie only one copy of the mutant gene is required to affect a transformation (e.g. Antennapedia: antenna-to-leg). Later, recessive mutations Antennapedia were discovered, which cause the reverse transformation (leg-to-antenna).

What is combinatorial control?

Combinatorial gene regulation provides a mechanism by which relatively small numbers of transcription factors can control the expression of a much larger number of genes with finely tuned temporal and spatial patterns.

What role do homeotic Hox genes play in embryonic development?

homeotic gene, any of a group of genes that control the pattern of body formation during early embryonic development of organisms. These genes encode proteins called transcription factors that direct cells to form various parts of the body.

Which scientists discovered the gene antennapedia?

Gehring identified the homeobox in 1983, with the help of colleagues while isolating the Antennapedia (Antp) gene in fruit flies (Drosophila) at the University of Basel in Basel, Switzerland.

What is a homeodomain protein?

The homeodomain is a highly conserved 60‐amino‐acid protein domain that is encoded by the homeobox and is found in organisms as diverse as mammals, insects, plants and yeast. Homeodomains function as DNA binding domains and are found in many transcription factors that control development and cell fate decisions.

Where is the antp gene active?

mesothorax
This result indicates that (1) the product of the wild-type Antp gene is normally active in the mesothorax where it promotes a mesothoracic pathway of development instead of an antennal pathway, (2) the Antp+ gene product is normally absent or inactive in the antenna, and (3) dominant mutations of the locus result in …

What is the antennapedia complex?

The Antennapedia complex (ANT-C) is one of two Hox gene complexes. Hox genes encode homeodomain transcription factors. ANT-C controls the identity of segments that contribute to the head and the anterior thorax. ANT-C homeotic genes show colinearity in their expression patterns with the exception of pb.

What is combinatorial control of gene expression in animals?

In eukaryotes, regulation of gene expression by transcription factors is said to be combinatorial, in that it requires the coordinated interactions of multiple proteins (in contrast to prokaryotes, in which a single protein is usually all that is required).

What does combinatorial control mean in biology?

[‚käm·bə·nə¦tȯr·ē·əl kən′trōl] (cell and molecular biology) Control of gene expression requiring presence or absence of a particular combination of regulatory proteins.