How do B cells become activated?

Activation of B cells

1. A B cell becomes activated when its receptor recognizes an antigen and binds to it.
2. Most antigens are T-dependent.
3. Interaction with antigens causes B cells to multiply into clones of immunoglobulin-secreting cells.
4. The process just described takes place among the circulating B lymphocytes.

Where does B cell activation occur?

B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph.

How are B cells activated in the presence of an antigen?

B-cell activation is initiated through binding of antigen by the B-cell receptor. This activation signal is greatly amplified by the B-cell co-receptor composed of CD19, CD21, and CD81 when antigen is complexed with components of the complement system.

Which of the following is responsible for B cell activation?

Which of the following is responsible for B-cell activation? Explanation: The activation of mature B-cell is done by antigen. When antigen come in contact with B-cells, it undergoes clonal proliferation and divided into memory cells and plasma cells.

What causes B cells to become plasma cells?

First, the B cells must encounter a foreign antigen and are then required to be activated by T helper cells before they differentiate into specific cells. Most of these B cells will become plasmablasts (or “immature plasma cells”), and eventually plasma cells, and begin producing large volumes of antibodies.

Where does B cell isotype switching occur?

Repetitive areas of DNA known as ‘switch regions’ are found in the introns upstream of each isotype gene, which is used to guide AID and other enzymes to the site.

Are B cells activated by cytokines?

TH cells activate B cells by their products, cytokines such as IL-4, IL-5, and IL-6, and membrane-bound stimulatory molecules including CD40 ligand. Each cytokine has pleiotropic activity on B cells and other cell types, and acts through a specific receptor.

Where does the B in B cells come from?

B-Cell. You might think B-cells got their name because they are made inside your bones. It is true that most blood cells are made inside the bone marrow, but that is not where the “B” in B-cells came from. Their name comes from the name of the place they were discovered, the Bursa of Fabricius.