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What drugs should be avoided in malignant hyperthermia?

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What drugs should be avoided in malignant hyperthermia?

What drugs trigger MH? All the inhalation anesthetics (desflurane, sevoflurane, isoflurane, methoxyflurane halothane, enflurane) and succinylcholine (a depolarizing muscle relaxant) are considered MH triggers.

What drugs trigger malignant hyperthermia?

According to the Malignant Hyperthermia Association of the United States (MHAUS), the following agents approved for use in the U.S. are known triggers of MH: inhaled general anesthetics, halothane, desflurane, enflurane, ether, isoflurane, sevoflurane, and succinylcholine.

What are non triggering agents for malignant hyperthermia?

Nitrous oxide, intravenous induction agents, benzodiazepines, opioids, and the non-depolarizing relaxants do not trigger MH.

Is nitrous safe for malignant hyperthermia?

Nitrous oxide is not associated with nephrotoxicity or hepatotoxicity and is safe to use in patients susceptible to malignant hyperthermia. It possesses an analgesic property that all modern anesthetics lack and is short acting, with quick onset and offset of action.

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Can propofol trigger malignant hyperthermia?

Abstract. Propofol may be a useful anesthetic in the management of malignant hyperthermia patients. It appears not to trigger malignant hyperthermia while providing stress-free conditions.

Can propofol cause malignant hyperthermia?

What anesthetics are safe for malignant hyperthermia?

Safe Anesthetic Agents for MH Patients:

  • Diazepam.
  • Etomidate (Amidate)
  • Hexobarbital.
  • Ketamine (Ketalar)
  • Methohexital (Brevital)
  • Midazolam.
  • Pentobarbital.
  • Propofol (Diprivan)

Which anesthetic agent is safe for malignant hyperthermia?

Propofol is a ‘safe’ anaesthetic agent in malignant hyperthermia susceptible patients. Anaesth Intensive Care.

How long after anesthesia can malignant hyperthermia occur?

Although the initial clinical signs of MH typically occur within one hour of anesthesia induction, the onset of MH can occur any time during the administration of triggering agents.

Is nitrous oxide safe with malignant hyperthermia?

Is Propofol safe for malignant hyperthermia?