What is an MCL-1 inhibitor?

An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities.

What does MCL-1 stand for?

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor types and is closely associated with tumorigenesis, poor prognosis and drug resistance.

What is MCL1 protein?

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria.

What is the survivin gene?

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family.

Is bad pro-apoptotic?

The BCL2 associated agonist of cell death (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. BAD is a member of the BH3-only family, a subfamily of the Bcl-2 family.

Is Bax pro-apoptotic?

The BAX gene was the first identified pro-apoptotic member of the Bcl-2 protein family. In the protein’s inactive form, the groove binds its transmembrane domain, transitioning it from a membrane-bound to a cytosolic protein.

What is the survivin promoter?

Conclusions: Together these data indicate that the survivin promoter is a promising tumor-specific promoter for transcriptional targeting of adenovirus-based vectors and CRAds for malignant gliomas.

What is the role of bid in apoptosis?

Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-mediated apoptosis in many cell systems. Bid action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

What is BIM protein?

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.

Does Bcl-2 bind to Bax?

The distinctive feature of the direct activation model is that a BH3 protein is required to directly bind and to activate the Bcl-2 multihomology region proapoptotic proteins, Bax and Bak.

Is Bak proapoptotic?

Two key members of the Bcl-2 family are the proapoptotic proteins Bax and Bak, which convert from harmless monomers into deadly oligomers that form pores in the MOM.