Can long term use of omeprazole cause kidney damage?

In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD.

Do PPIs cause permanent kidney damage?

PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD).

Can PPIs cause kidney problems?

Proton pump inhibitors (PPIs), long thought to be safe, are associated with a number of nonkidney adverse health outcomes and several untoward kidney outcomes, including hypomagnesemia, acute kidney injury, acute interstitial nephritis, incident chronic kidney disease, kidney disease progression, kidney failure, and …

Is omeprazole safe to take with kidney disease?

A recent University of Buffalo study examining the side effects of heartburn medications has shown a connection between common acid reflux drugs and acute kidney failure. The research indicates that continued use of medications including omeprazole may be bad for your kidneys.

Will stopping omeprazole improve kidney function?

Lastly, although the observational studies above linked PPI use to CKD progression, there is no evidence suggesting that kidney function will improve after cessation of PPIs.

What are the risks of taking omeprazole long-term?

Prilosec (omeprazole) is a proton pump inhibitor that treats severe stomach acid-related conditions like GERD. Common Prilosec side effects include headache, stomach pain and nausea. Long-term Prilosec use has been linked to kidney damage, bone fractures and other dangerous side effects.

Does omeprazole affect creatinine levels?

While omeprazole did not increase serum creatinine or urea, which is consistent with its well-known lack of severe nephrotoxic potential, as is evident from its widespread clinical use, kidney expression of the tubular cell injury marker NGAL was increased (Fig.

Are antacids bad for your kidneys?

Upset stomach/antacid medications. This group of over-the-counter medications can disrupt the body’s electrolyte balance if you have chronic kidney disease. Check with your doctor to see if these are safe for you to use.

Is PPI kidney damage reversible?

Over five years of follow up, the researchers found that more than 80 percent of PPI users did not develop acute kidney problems, which often are reversible and are characterized by too little urine leaving the body, fatigue and swelling in the legs and ankles.

Is taking omeprazole daily safe?

You should not take it for more than 14 days or repeat a 14-day course more often than every 4 months unless directed by a doctor. Do not crush, break, or chew the tablet. This decreases how well Prilosec OTC works in the body.