Can you sacrifice a creature in response to a spell?

Explicitly as this question is asked, no you cannot sacrifice something while it is being destroyed. However, what you want to do is possible. The spell that destroys all creatures goes onto the stack and both players are then allowed to take actions before it resolves.

Does sacrificing a creature count as it being destroyed?

Sacrificing a permanent doesn’t destroy it, so regeneration or other effects that replace destruction can’t affect this action. Sometimes-relevant corner cases: Tokens disappear when they leave the battlefield, but they still count as going to the graveyard, so you do get Captain triggers.

Can you sacrifice a targeted creature?

Yes, you can target one of your permanents with a spell or ability, then sacrifice that permanent to pay for that very spell or ability. When casting a spell or activating an ability, you first put it on stack, then choose targets (the creature you are about to sacrifice), then pay all costs (sacrifice the creature).

Can I sacrifice in response to a sacrifice?

No, you can’t lock in that creature for sacrifice. If you do respond to Eldrazi Monument and sacrifice a creature, it just means that that particular creature won’t exist when you are told by Eldrazi Monument to “sacrifice a creature”.

Can you sacrifice something twice MTG?

So to answer your actual question, you cannot “double dip” in this way. You can only sacrifice it for one effect.

Can you regenerate a destroyed creature?

You can’t regenerate a destroyed creature because it’s already dead and gone so there’s nothing to regenerate. This means that you have to grant regeneration before lethal is dealt. Regeneration functions as a “replacement effect”, meaning that the effect waits for one conditional event to replace with another.

Can I regenerate a sacrificed creature?

Description. Sacrificing or saccing is purposely or forcefully removing a permanent from play. This can be due to an effect on the card itself, the effect of another permanent already in play, coming into or leaving play or a spell such as an instant or sorcery. A sacrificed permanent cannot be regenerated.

Can you sacrifice a creature with indestructible?

Description. Indestructible permanents can still be put into their owner’s graveyard by other means, such as by the “legend rule”, by being sacrificed or (in the case of creatures) having zero or less toughness. They can also be removed from the battlefield by being bounced or exiled for example.

Can you counter a sacrifice?

Yes, you can sacrifice the creature in response to targeting it with the enter the battlefield triggered ability and that will result in the ability being countered (fizzle) because it has no legal targets when it resolves and no -1/-1 counters will get placed on anything.

Can you sacrifice curses?

Nope. You can only sacrifice something you control. While their aura may be attached to your creature, they still control the enchantment, not you.

Can you sacrifice a creature for multiple effects?

You cannot sacrifice one creature for all the effects of A, C, D, E because sacrificing a creature is a cost and you must be able to pay each and every cost.