What is the purpose of dornase alfa?
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What is the purpose of dornase alfa?
Dornase alfa is used to reduce the number of lung infections and to improve lung function in patients with cystic fibrosis. It breaks down the thick secretions in the airways, allowing air to flow better and preventing bacteria from building up.
When do you give dornase alfa?
The Cystic Fibrosis Foundation’s guidelines, “Chronic Medications for Maintenance of Lung Health,” recommend the use of dornase alfa in people with CF ages 6 years and older to improve lung function. Lung function includes how well air moves in and out, and how well the lungs bring in oxygen and blow out carbon dioxide …
How effective is dornase alfa?
Patients treated with dornase alfa had lower pulmonary functions, more bacterial colonization, and more exacerbations at baseline (FEV1 : 76.0\% vs 87.6\%, Pseudomonas aeruginosa : 64.1\% vs 46.7\%, pulmonary exacerbations during the previous 6 months: 56.4\% vs 22.
Is dornase alfa adverse effects?
| Adverse Reactions (of any severity or seriousness) | Trial 1 CF Patients with FVC ≥ 40\% of predicted treated for 24 weeks | |
|---|---|---|
| Pharyngitis | 33\% | 40\% |
| Rash | 7\% | 12\% |
| Laryngitis | 1\% | 4\% |
| Chest Pain | 16\% | 21\% |
Is dornase alfa expensive?
Pulmozyme (dornase alfa) works well to thin your mucus and help you breathe easier, but it is very expensive and requires a nebulizer.
How do you use dornase alfa?
To use:
- Dornase alfa inhalation solution comes in small plastic containers called ampules.
- Remove the ampule from the pouch.
- Connect the nebulizer to the face mask or mouthpiece, then connect the nebulizer to the compressor.
- Use the mouthpiece of the nebulizer to breathe in Pulmozyme®.
Is Dornase Alfa expensive?
What can I put in my nebulizer for phlegm?
Sterile saline solution: A nebulizer can deliver sterile saline to help open the airways and thin secretions. This may loosen and make it easier to cough up mucus in the lungs.
How long does it take for Dornase to work?
Although it is accepted that maximal spirometric responses to dornase alfa are achieved after 2 weeks of treatment, long-term studies suggest that they reach a peak at 1-2 weeks [5] or 4-12 weeks [6] of treatment but shorter time intervals have not been studied.
What category is dornase alfa?
Enzymes
Pulmozyme is a prescription medicine used to treat the symptoms of Cystic Fibrosis. Pulmozyme may be used alone or with other medications. Pulmozyme belongs to a class of drugs called Enzymes, Mucolytic.
What is the drug classification of dornase alfa?
Dornase alfa is a medication used in the management and treatment of cystic fibrosis. It is in the category B class of drugs. This activity outlines the indications, action, and contraindications for dornase alfa as a valuable agent in the therapy for cystic fibrosis, pleural effusion, and emphysema.
Is Pulmozyme a specialty drug?
Pulmozyme Access Solutions works with specialty pharmacies (SPs) to help patients receive their medicines. An SP may provide the following services: Clinical services to support patients throughout their treatment.
How do you use Dornase alfa?
Dornase alfa should be used with the eRapid™ nebulizer system or a jet nebulizer that is connected to an air compressor. An air compressor is used with a nebulizer to turn the medicine into a fine spray. You will breathe in the spray through your mouth.
Can I take Dornase alfa If I have cystic fibrosis?
Dornase alfa is used to treat cystic fibrosis but does not cure it. Continue to use dornase alfa even if you feel well. Do not stop using dornase alfa without talking to your doctor.
How should I take care of my Dornase alfa nebulizer?
Do not dilute or mix dornase alfa with other drugs in the nebulizer. Inhalation devices require regular cleaning. Follow the manufacturer’s written instructions for the care of the nebulizer. Do not let anyone else use your medication.
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