Why is thalassemia test necessary?
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Why is thalassemia test necessary?
The tests will show whether any family members have missing or altered hemoglobin genes. If you know of family members who have thalassemias and you’re thinking of having children, consider talking with your doctor and a genetic counselor. They can help determine your risk for passing the disorder to your children.
What is the problem with thalassemia?
Thalassemia (thal-uh-SEE-me-uh) is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued. If you have mild thalassemia, you might not need treatment.
Is thalassemia test required in pregnancy?
Prenatal diagnosis of β thalassemia using CVS can be carried out at 9–11 weeks. Amniocentesis can be carried out in 14–18 weeks of pregnancy; fetal blood testing can be done in 18–20 weeks of pregnancy….Table 3.
| Hemoglobinopathy | No. of patients |
|---|---|
| β thalassemia trait | 28 |
| Thal trait Hb E | 1 |
| Hb D Punjab | 3 |
| Hb J | 1 |
What research is being done for thalassemia?
Scientists are working to develop a gene therapy that may offer a cure for thalassemia. Such a treatment might involve inserting a normal beta globin gene (the gene that is abnormal in this disease) into the patient’s stem cells, the immature bone marrow cells that are the precursors of all other cells in the blood.
Why blood test is necessary for thalassemia before marriage?
When two such thalassaemia carriers marry and plan to have children there is a one-in-four chance of having a thalassaemic baby at every conception. A simple blood test for thalassaemia before marriage will let couples know if they are carriers or not.
Why does thalassemia occur?
Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells.
Who is at risk of thalassemia?
Certain ethnic groups are at greater risk: Alpha thalassemia most often affects people who are of Southeast Asian, Indian, Chinese, or Filipino descent. Beta thalassemia most often affects people who are of Mediterranean (Greek, Italian and Middle Eastern), Asian, or African descent.
What is thalassemia test before marriage?
What is the probability of getting thalassemia?
1 in 2 chance each child you have will be a carrier of thalassaemia, but will not have the condition themselves. 1 in 4 chance each child you have will be born with thalassaemia.
What is the future of thalassemia?
Future treatments for beta-thalassemia will depend on the benefit/risk/cost ratios for conventional transfusion and iron chelation [70], γ-globin induction [186], allogeneic bone marrow transplantation [187] and gene therapy [170], and the availability of these treatments in the low-income countries in which most β- …
What happens if both husband and wife have thalassemia?
If you have thalassemia and your partner carries the trait for thalassemia, there is a chance that your baby may inherit the disease. The stress of pregnancy can make the symptoms of thalassemia worse and cause complications such as anemia and stress on the heart.
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