Can pantoprazole cause QT prolongation?

PPIs do not directly cause prolongation of the QT interval, but they have been associated with hypomagnesemia, which is often accompanied by hypocalcemia and hypokalemia and can result in cardiac repolarization disturbances such as QT interval prolongation.

Can pantoprazole cause heart arrhythmia?

In these patients, PPIs can potentiate the hypomagnesemia-induced lethal arrhythmias, which can result in sudden cardiac death.

Can pantoprazole affect heart rate?

Infusion of pantoprazole at increasing rates lead to a significant decline of end systolic LV pressure by decreasing heart rate, myocardial contractility and arterial elastance. These effects were quick, beginning immediately with the infusion and usually reaching a plateau after 2 or 3 min of infusion.

Is torsades de pointes fatal?

Torsades de Pointes is a specific type of ventricular tachycardia, or fast heart rhythm that begins in your heart ventricles. You can get it if you inherited Long QT syndrome or if you take certain medicines. Although Torsades de Pointes can be deadly if untreated, treatment greatly improves your outlook.

What are the side effects of pantoprazole?

Pantoprazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache.
• nausea.
• vomiting.
• gas.
• joint pain.
• diarrhea.
• dizziness.

Does pantoprazole affect blood pressure?

Omeprazole, lansoprazole and pantoprazole had no effect on blood pressure and electrocardiogram of anesthetized rat. Pharmacol Res. 2008 Jul;58(1):65-71.

Which of the following drug is not responsible for QT prolongation?

Drug interactions affecting the cytochrome P450 system and potential inhibition of the IKr channels are most likely the cause of QT prolongation. Newer nonsedating antihistamines (e.g., loratadine, fexofenadine, and cetirizine) have not been linked to this risk.

What increases QT interval?

Causes of acquired long QT syndrome Certain antifungal medications taken by mouth used to treat yeast infections. Diuretics that cause an electrolyte imbalance (low potassium, most commonly) Heart rhythm drugs (especially anti-arrhythmic medications that lengthen the QT interval)

What are the bad side effects of pantoprazole?

What are the most common side effects of pantoprazole?

COMMON side effects

• joint pain.
• dizziness.
• headache.
• nausea.
• vomiting.
• gas.
• diarrhea.
• intense abdominal pain.