Does lithium orotate really work?

Lithium orotate has been used as a mood stabilizer for many years, and can be highly effective in treating mood swings, anger and aggression, attention deficit disorder, depression and anxiety.

Why is lithium no longer prescribed?

Adverse effects were the most common cause for lithium discontinuation. Among the adverse effects, diarrhoea, tremor, creatinine increase, polyuria/polydipsia/diabetes insipidus and weight gain were the top five reasons for discontinuing lithium.

Is it safe to take lithium orotate?

Lithium carbonate and lithium citrate have been approved by the U.S. Food and Drug Administration (FDA). But not enough is known about the safety of lithium orotate. Avoid using lithium orotate until more is known. Lithium can cause nausea, diarrhea, dizziness, muscle weakness, fatigue, and a dazed feeling.

Is lithium orotate more effective than lithium carbonate?

Another form of lithium called lithium orotate, is preferred because the orotate ion crosses the blood-brain barrier more easily than the carbonate ion of lithium carbonate. Therefore, lithium orotate can be used in much lower doses (e.g. 5 mg) with remarkable results and no side effects [49,50].

Does lithium orotate increase GABA?

At a neuronal level, lithium reduces excitatory (dopamine and glutamate) but increases inhibitory (GABA) neurotransmission; however, these broad effects are underpinned by complex neurotransmitter systems that strive to achieve homeostasis by way of compensatory changes.

Does lithium orotate increase dopamine?

As we can see in this slide, lithium modulates neurotransmitters. It inhibits excitatory neurotransmitters such as dopamine and glutamate, and promotes GABA-mediated neurotransmission.

What is better than lithium for bipolar?

July 8, 2005 — Olanzapine is better than lithium at preventing manic and mixed-episode relapse and recurrence, according to the results of a randomized trial published in the July issue of the American Journal of Psychiatry.