What does it mean if CH50 is high?

An elevated CH50 indicates high level of activity of the classical pathway of the complement system, but does not have any specific clinical meaning except suggesting the presence of active inflammation and immune activation. An undetectable CH50 can indicate the complete deficiency of any component of the system.

What does complement 60 mean?

Complement is a blood test that measures the activity of certain proteins in the liquid portion of your blood. The complement system is a group of nearly 60 proteins that are in blood plasma or on the surface of some cells.

What infections cause elevated CH50?

Elevated complement may be found in acute inflammatory conditions, leukemia, Hodgkin’s Disease, sarcoma, and Behcet’s Disease.

What is measured in the CH50 assay?

The classic CH50 test is a complement function assay that measures the ability of serum to lyse antibody-sensitized sheep erythrocytes via complement classical pathway mediated formation of the membrane attack complex (MAC).

What is CH50 normal range?

Adult reference range is 42 to 95 U/mL. A low CH50 suggests the possibility of a complement factor deficiency.

What does a low complement total CH50 mean?

Low levels of total complement (total hemolytic complement) may occur during infections, disease exacerbation in patients with systemic lupus erythematosus, and in patients with immune complex diseases such as glomerulonephritis. Undetectable levels suggest the possibility of a complement component deficiency.

What is CFI disease?

Description. Collapse Section. Complement factor I deficiency is a disorder that affects the immune system. People with this condition are prone to recurrent infections, including infections of the upper respiratory tract, ears, skin, and urinary tract.

How does a CH50 test work?

The test is based on the capacity of an individual’s serum to lyse sheep erythrocytes coated with anti-sheep antibodies (preferably rabbit IgG). The individual’s serum is diluted until the minimum concentration is reached that 50\% of the sheep red blood cells are lysed, and that concentration is recorded as the CH50.

What is the purpose of the total complement activity CH50 assay quizlet?

TestNew stuff! It a crucial part of the immune system that utilizes soluble serum proteins for chemotaxis, opsonization, and direct pathogen destruction.

What is the utility of CH50 test?

The primary utility of the CH50 in the practice of an allergist-immunologist is to screen for complement-deficiency associated immunodeficiency (primarily classic or termi- nal complement component deficiencies) and some vasculitides (usually immune-complex in- duced and/or small vessel vasculitis).

Is CH50 high in lupus?

The CH50 is typically below normal. Up to 25\% of patients with SLE, however, may have much more dramatic reductions in C4 levels, typically associated with significantly subnormal C3 levels and CH50.

What is iC3b complement?

iC3b is a protein fragment that is part of the complement system, a component of the vertebrate immune system. iC3b is produced when complement factor I cleaves C3b. Complement receptors on white blood cells are able to bind iC3b, so iC3b functions as an opsonin.