Which is coincidence detector?

Coincidence detector or coincidence detection can refer to: Coincidence circuit, a device that can detect simultaneous electric signals. Coincidence detection in neurobiology, the detection of temporally close but spatially distributed input signals.

What receptor function is a coincidence detector?

Excitatory synapses have typically been the focus of studies of synaptic plasticity, and many years of research have shown that the NMDA-type glutamate receptor serves as the ‘coincidence detector’, allowing the postsynaptic neuron to respond to inputs that arrive at about the same time with long-term changes in the …

What is coincidence detection cell signaling?

… Coincidence detection is a process whereby peripheral membrane proteins are recruited to specific cellular compartments required for their function by multiple coordinated molecular interactions (Carlton and Cullen 2005) .

Are AMPA receptors coincidence detectors?

We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.

What is the purpose of coincidence?

When we specifically experience and live a coincidence (an unexpected encounter, a turn of event in our favor, a sign), we increase our sense of belonging to our life because our curiosity and our desire to know about this world are then aroused.

What is the coincidence detector in all of the associative pathways discussed in the hippocampus?

A model for associative LTD in the hippocampus. PKC and PICK1 are the coincidence detectors for the activation of metabotropic glutamate receptors and the Ca2+ influx through voltage-dependent Ca2+ channels.

How does the NMDA receptor detect an action potential in the presynaptic cell?

Glutamate binds to the NMDA receptor, opening it to allow Ca++ ions to flow into the postsynaptic cell. Because these AMPA receptors provide the primary excitatory input drive on the neuron, changing them changes the net excitatory effect of a presynaptic action potential on the postsynaptic neuron.

Which glutamate receptor is necessary for LTP and acts as a coincidence detector?

In the adult visual cortex, activation of N-methyl-d-aspartate (NMDA) glutamate receptors is necessary to induce this plasticity. These receptors act as coincidence detectors, sensing presynaptic glutamate release and postsynaptic depolarization, and cause an influx of Ca(2+) that is necessary for the potentiation.

What is synaptic potentiation?

Abstract. Long-term synaptic potentiation (LTP) is a leading candidate for a synaptic mechanism of rapid learning in mammals. LTP is a persistent increase in synaptic efficacy that can be quickly induced.

What is the theory of coincidence?

A coincidence may be synchronicity, that being the experience of events that are causally unrelated, and yet their occurrence together has meaning for the person who observes them. They argue that probability and statistical theory (exemplified, e.g., in Littlewood’s law) suffice to explain remarkable coincidences.

How does science explain coincidence?

The very definition of coincidence relies on us picking out similarities and patterns. “Once we spot a regularity, we learn something about what events go together and how likely they are to occur,” says Magda Osman, an experimental psychologist at the University of London and one of the study’s authors.

Which receptor type is critical for the coincidence detection in hippocampal ca1 long-term potentiation?

Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-d-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre- and postsynaptic neurons.