Can Metaplastic breast cancer be cured?

Metaplastic breast cancer (MpBC) is a rare type of fast-growing breast cancer that can spread anywhere in the body. Doctors often detect it in the later stages, so it is not curable, but treatment can help people manage the disease.

What is the most common route of metastasis for breast cancer?

Metastasis or tumor cell dissemination occurs via the hematogenous and lymphatic systems. For many carcinomas, the dissemination of tumor cells via lymphatic drainage of the tumor is the most common metastatic route.

How fast does metaplastic breast cancer grow?

Metaplastic breast cancer recurs more often and more quickly compared to IDC and LDC. It has a peak recurrence rate of 18 months to 3-5 years after treatment.

What is the difference between metastatic and metaplastic breast cancer?

It can be benign (noncancerous), but it can be a pre-cancerous change. Metastatic breast cancer. Breast cancer of any type that has spread outside the breast to distant parts of the body is metastatic. Breast cancer can be both metaplastic and metastatic, and metaplastic cancer has a high risk of metastasizing.

How long does breast cancer take to metastasize?

According to the Robert W. Franz Cancer Research Center at Providence Portland Medical Center, breast cancer cells need to divide at least 30 times before they are detectable by physical exam. Each division takes about 1 to 2 months, so a detectable tumor has likely been growing in the body for 2 to 5 years.

Can breast cancer metastasis if not in lymph nodes?

cancers that originally had no lymph node involvement can recur and develop metastatic disease. the body, where they take up residence and continue to grow and divide in that one particular spot.

Is metaplastic breast cancer invasive?

Metaplastic breast cancer is a rare type of breast cancer accounting for around 1\% of breast cancers. Metaplastic breast cancer is an invasive cancer, which means it has the potential to spread to other parts of the body.

Is Metaplastic breast cancer invasive?

What stage is Metaplastic breast cancer?

Most metaplastic breast cancers are grade 3 at diagnosis. MpBC begins as one type of cell, typically epithelial cells, which are the cells that line the ducts and lobules, and then morphs into mesenchymal cells.

What is metaplastic breast cancer?

1. Introduction Metaplastic breast cancer (MBC) is a rare malignancy characterized by the histologic presence of two or more cellular types, commonly a mixture of epithelial and mesenchymal components [1–6]. MBC represents 0.25–1\% of breast cancers diagnosed annually [1, 7, 8].

What is the prognosis of metastatic breast cancer (mBC)?

MBC is rare relative to invasive ductal carcinoma (IDC), representing less than 1\% of all breast cancers. Other than a lower rate of lymph node metastases, MBC tumors display poorer prognostic features relative to IDC. Due to its low incidence and pathological variability, the ideal treatment paradigm for MBC is unknown.

What is the pathophysiology of MPBC in breast cancer?

MpBC is defined by the histological presence of at least two cellular types, typically epithelial and mesenchymal components. This variant harbors a triple-negative breast cancer (TNBC) phenotype, yet has a worse prognosis and decreased survival compared to TNBC. There are currently no standardized treatment guidelines specifically for MpBC.

What are the contraindications for breast conservation therapy?

Large tumors (≥5 cm) are a relative contraindication to breast conservation therapy [12] and even less extensive tumors may preclude breast conservation in smaller-breasted patients. These guidelines are particularly important for MBC patients, as they typically present with larger tumors compared to their IDC counterparts [8, 13].