Which drug is contraindicated in active tuberculosis?

The following antituberculosis drugs are contraindicated in pregnant women: Streptomycin. Kanamycin. Amikacin.

Which treatment is used for treating active tuberculosis?

The most common treatment for active TB is isoniazid INH in combination with three other drugs—rifampin, pyrazinamide and ethambutol. You may begin to feel better only a few weeks after starting to take the drugs but treating TB takes much longer than other bacterial infections.

What are complications of active tuberculosis?

Back pain and stiffness are common complications of tuberculosis. Joint damage. Arthritis that results from tuberculosis (tuberculous arthritis) usually affects the hips and knees. Swelling of the membranes that cover your brain (meningitis).

What is the most active agent for the clinical treatment of tuberculosis?

Most common TB drugs The most common medications used to treat tuberculosis include: Isoniazid. Rifampin (Rifadin, Rimactane) Ethambutol (Myambutol)

Why combination therapy is used in tuberculosis?

Treating a tuberculosis patient with a monotherapy of rifampicin rapidly leads to resistance to the drug even if it is given for short periods only. In combination drugs, the presence of isoniazid reduces the probability for the survival of rifampicin-resistant mutants.

How does tuberculosis become active?

TB bacteria become active if the immune system can’t stop them from growing. When TB bacteria are active (multiplying in your body), this is called TB disease. People with TB disease are sick. They may also be able to spread the bacteria to people they spend time with every day.

What is the difference between latent and active TB?

People with latent TB do not have any symptoms and cannot spread TB. If they do not get treatment, however, they may develop active TB disease in the future, spread the disease to others, and feel quite ill. People with active TB disease can be treated and cured if they get medical help.

Why is proper antibiotic therapy especially important for patients with tuberculosis?

A long treatment is required because antibiotics work only when the bacteria are actively dividing, and the bacteria that cause TB can rest without growing for long periods. This treatment is necessary to keep the latent TB infection from developing into active disease.

Why is combination therapy used?

The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant cancer cells will develop. When drugs with different effects are combined, each drug can be used at its optimal dose, without intolerable side effects.

What are the important reasons for multidrug treatment or drug combinations for the treatment of tuberculosis?

Multidrug therapy is necessary to cure tuberculosis patients and to prevent the selection of drug-resistant mutants, which may arise during the course of treatment.