Which of the following react with Grignard reagent?

Grignard Reagents. The Grignard Reaction is the addition of an organomagnesium halide (Grignard reagent) to a ketone or aldehyde, to form a tertiary or secondary alcohol, respectively. The reaction with formaldehyde leads to a primary alcohol.

What can destroy Grignard reagents?

The Grignard reagent is destroyed by reaction with acidic hydrogen atoms of water, alcohols, phenols, or carboxylic acid groups. For the same reason, we must consider the structure of the carbonyl compound selected for reaction with a Grignard reagent.

Can a Grignard reagent react with itself?

The problem here, as you might have guessed if you read the last post, is that this Grignard reagent reacts with itself!!! Once formed, the Grignard would react with the ketone from the starting material. This could then react with Mg to give a new Grignard, which would react with more ketone… and so on.

Does Grignard reagent react with double bond?

General Reaction between Grignards and carbonyls The reactions between the various sorts of carbonyl compounds and Grignard reagents can look quite complicated, but in fact they all react in the same way – all that changes are the groups attached to the carbon-oxygen double bond.

What other functional groups will be incompatible with a Grignard reagent?

Alcoholic solvents and water are incompatible with Grignard reagents and organolithium reagents. Reactive functional groups: aldehydes, ketones, esters, amides, halides, -NO2, -SO2R, nitriles The solvent or alkyl halides can not contain functional groups that are electrophilic or acidic.

Which of the following reacts with Grignard reagent to form an addition product?

Carboxylic acids can be prepared using Grignard reagents.

Why can’t Grignard reagents react with water?

Grignard formation does not involve a radical chain mechanism. It is a non-chain radical reaction. Water or alcohols would protonate and thus destroy the Grignard reagent, because the Grignard carbon is highly nucleophilic.

Do Grignard reagents react with ketones?

Organolithium or Grignard reagents react with the carbonyl group, C=O, in aldehydes or ketones to give alcohols. The substituents on the carbonyl dictate the nature of the product alcohol. Addition to ketones gives tertiary alcohols.

Which reactions do not need to be protected using an acetal?

Because acetals are unstable in acid, they do not protect carbonyl groups under acidic conditions.