What is a Tzanck cells?

A typical Tzanck cell is a large, rounded keratinocyte with a hypertrophic nucleus, hazy or absent nucleoli and abundant basophilic cytoplasm, which is deeper peripherally on the cell membrane due to cytoplasmic condensation at the periphery, leading to a perinuclear halo.

What does Acantholytic mean?

Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders.

Is PV an autoimmune disease?

Pemphigus vulgaris is an autoimmune disorder that involves blistering and erosion of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. The primary lesion of pemphigus vulgaris is a soft blister filled with clear fluid that appears on healthy or irritated skin.

Does Grover’s disease go away?

Though there isn’t a known cause for Grover’s disease, it does go away. Following a correct diagnosis, most cases last 6 to 12 months. Staying in contact with your dermatologist is key to ensuring your symptoms clear up and don’t return.

What is the brand name for acyclovir?

ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. ZOVIRAX Ointment 5\% is a formulation for topical administration.

What is acyclovir ointment used for?

Acyclovir ointment is used to treat first outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time) and to treat certain types of sores caused by the herpes simplex virus in people with weak immune systems.

What does Giemsa stain?

Giemsa stain is a classic blood film stain for peripheral blood smears and bone marrow specimens. Erythrocytes stain pink, platelets show a light pale pink, lymphocyte cytoplasm stains sky blue, monocyte cytoplasm stains pale blue, and leukocyte nuclear chromatin stains magenta.

What giemsa means?

Giemsa is a dye consisting of methylene blue-eosin and methylene blue. It is named after Gustav Giemsa, a German chemist and bacteriologist. This dye solution is used in histopathologic diagnosis. It is used in staining blood films. It can also stain Histoplasma (a fungus) and Chlamydia (a bacterium).

Who gets pemphigus vulgaris?

Who gets pemphigus vulgaris? Pemphigus vulgaris affects people of all races, age, and sex. It most commonly appears between the ages of 30 and 60 years and is more common in Jews and Indians than in other races, presumably for genetic reasons.