What is MHC and why does it matter?

The major histocompatibility complex (MHC) genes code for proteins which the immune system uses to identify cells and tissues in the body as “self” or “other”. It presents snippets of information (peptides) on the state of the cell- allowing the immune system to check for infection, cancer, and other maladies.

Which immune cells have MHC?

Figure 1. MHC I are found on all nucleated body cells, and MHC II are found on macrophages, dendritic cells, and B cells (along with MHC I).

What is the structure and function of MHC?

The protein products of the MHC have been classified into three classes: class I and II (both of which are involved in antigen presentation) and III molecules. Class I and II proteins are integral components of the immune system whose primary role is the presentation of peptide antigen to T-cell receptor.

Who is discovered by immunology?

As a student of immunology, I learned that Louis Pasteur was really the father of immunology, despite Edward Jenner’s pioneering introduction of vaccination to prevent smallpox in 1798 (Smith, 2011).

Why MHC is formed in immune system?

MHC proteins are found in all higher vertebrates. In human beings the complex is also called the human leukocyte antigen (HLA) system. MHC molecules are important components of the immune system because they allow T lymphocytes to detect cells, such as macrophages, that have ingested infectious microorganisms.

Who is the first used in immunity?

Around the 15th century in India, the Ottoman Empire, and east Africa, the practice of inoculation (poking the skin with powdered material derived from smallpox crusts) was quite common. This practice was first introduced into the west in 1721 by Lady Mary Wortley Montagu.

What is the role of MHC class 2?

The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.