How do you scale-up a bioreactor?
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How do you scale-up a bioreactor?
The traditional method for scale-up of a fermentation process involves determining the reactor geometry, impeller speed, and aeration rate of the large-scale bioreactor on the basis of the experimental results of the lab-scale bioreactor.
What is a scale-up process?
Cambridge Dictionary defines scale-up as increasing something in size, amount, or production. Microbial processes involve cultivation of microbes in bioreactors (also referred to as fermentors) to produce a product, as well as the subsequent recovery and purification of the product and disposal of associated wastes.
How is scale-up achieved in bioprocess technology?
One of the most widely accepted scale-up strategies is to maintain a constant impeller power consumption per liquid volume (P/V). This is carried out by adapting the impeller size and shape to the different working volumes.
What is scale-up of fermentation process?
The essence of scale-up of a fermentation process is to demonstrate fermentation production at large scale resulting in the same productivity and quality as that developed at small scale.
What happens in a bioreactor?
Bioreactors are vessels that have been designed and produced to provide an effective environment for enzymes or whole cells to transform biochemicals into products. In some cases, inactivation of cells or sterilization is carried out in the bioreactor such as in water treatment.
What is oxygen transfer rate in bioreactor?
The oxygen transfer rate (OTR) through an interface is calculated as the multiplicative product of the mass transfer coefficient, the specific transfer area, and the concentration driving force. In a bioreactor for cell cultivation, oxygen is typically supplied by blowing air into the culture medium through a sparger.
What is scale up in biotechnology?
Scaling up is the process of expanding a process from small scale to a larger scale.
What is scale-up in biotechnology?
What is meant by scale-up and scale down?
Network function virtualization defines these terms differently: scaling out/in is the ability to scale by adding/removing resource instances (e.g., virtual machine), whereas scaling up/down is the ability to scale by changing allocated resources (e.g., memory/CPU/storage capacity).
What is the main function of bioreactor?
Bioreactor Design The main function of a properly designed bioreactor is to provide a controlled environment to achieve optimal growth and/or product formation in the particular cell system employed.
What are bioreactors how is it useful in biotechnology?
Industrial Biotechnology and Commodity Products Bioreactors are vessels that have been designed and produced to provide an effective environment for enzymes or whole cells to transform biochemicals into products. Bioreactors used for DNA and protein synthesis (biomolecular synthesizers) are included.