Does venlafaxine cause QT prolongation?

Venlafaxine is the only SNRI listed on the CredibleMeds list of drugs that is associated with reports of QTc prolongation. Rare QT prolongation has been described with venlafaxine at therapeutic doses and overdoses.

What is drug induced long QT syndrome?

The drug-induced long QT syndrome (diLQTS1) describes a clinical entity in which administration of a drug produces marked prolongation of the QT interval of the electrocardiogram, associated with the development of a morphologically distinctive polymorphic ventricular tachycardia, termed torsades de pointes (TdP).

How do drugs cause QT prolongation?

Drug interactions affecting the cytochrome P450 system and potential inhibition of the IKr channels are most likely the cause of QT prolongation. Newer nonsedating antihistamines (e.g., loratadine, fexofenadine, and cetirizine) have not been linked to this risk.

Which antidepressants cause QT prolongation?

QT prolongation appears to be a class effect for all selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), and also occurs with venlafaxine. The potential for QT prolongation to occur should be considered as part of the risk benefit assessment prior to prescribing an antidepressant.

What drugs affect QT interval?

Drugs Causing QT Prolongation

• Chlorpromazine.
• Haloperidol.
• Droperidol.
• Quetiapine.
• Olanzapine.
• Amisulpride.
• Thioridazine.

What is drug-induced TdP?

Torsades de pointes (TdP) is an ECG manifestation characterized by a form of ventricular tachycardia with a spiral appearance and complexes that first look positive and then negative. Drug-induced QT prolongation acts as a marker for risk of progression to TdP.

Does Celexa cause QT prolongation?

Citalopram causes dose-dependent QT interval prolongation, which can cause Torsades de Pointes, ventricular tachycardia, and sudden death. Citalopram is not recommended for use at doses greater than 40 mg per day because such doses cause too large an effect on the QT interval and confer no additional benefit.

Which antidepressant has the least QT prolongation?

Based on current literature, fluoxetine, fluvoxamine, and sertraline appear to have similar, low risk for QT prolongation, and paroxetine appears to have the lowest risk.