What is meant by negative sense RNA?

Their genomes are negative sense, meaning that messenger RNA (mRNA) can be synthesized directly from the genome by the viral enzyme RNA-dependent RNA polymerase (RdRp), also called RNA replicase, which is encoded by all −ssRNA viruses.

What is the difference between negative and positive-sense RNA viruses?

Positive-sense viral RNA is similar to mRNA and thus can be immediately translated by the host cell. Negative-sense viral RNA is complementary to mRNA and thus must be converted to positive-sense RNA by an RNA polymerase before translation.

Why is the genomic RNA of negative strand RNA viruses such as influenza viruses is not infectious?

The RNA found in a negative-sense virus is not infectious by itself, as it needs to be transcribed into positive-sense RNA. The complementary plus-sense mRNA must be made before proteins can be translated from the viral genome.

Where do negative-strand RNA viruses replicate?

Many replicate in the cytoplasm, a few replicate in the nucleus. Viral genomes are often tightly associated with a nucleocapsid (N) protein. Families of negative-strand RNA viruses include Orthomyxoviridae, Paramyxoviridae, Rhabdoviridae, Bornaviridae, and Filoviridae.

Which of the following viruses is an example of a negative stranded RNA virus?

Examples of negative-strand RNA viruses include influenza virus, measles viruses, and rabies virus.

Why must a negative sense RNA virus carry its RNA dependent RNA polymerase in the virion?

The viron RNA is negative sense (complementary to mRNA and cannot encode proteins ), which means it must be replciated over to mRNA before protein production can begin. This is carried out by an RNA-dependent RNA-polymerase.

What is meant by a negative strand?

Negative-strand RNA virus: Also known as an antisense-strand RNA virus, a virus whose genetic information consists of a single strand of RNA that is the negative or antisense strand which does not encode mRNA (messenger RNA).

What is positive and negative strand of DNA?

Depending on the context, sense may have slightly different meanings. For example, negative-sense strand of DNA is equivalent to the template strand, whereas the positive-sense strand is the non-template strand whose nucleotide sequence is equivalent to the sequence of the mRNA transcript.

What are the basis on which positive and negative sense Rnas are classified?

Classification is based principally on the type of genome (double-stranded, negative- or positive-single-strand) and gene number and organization. Currently, there are 5 orders and 47 families of RNA viruses recognized. There are also many unassigned species and genera.

What is a negative strand DNA?

A minus strand is a noncoding strand that must be copied by an RNA-dependent RNA polymerase to produce a translatable mRNA. 2. in a single-stranded DNA virus, a plus strand is one contained in the virus particle or any strand having the same base sequence.