Why is adenovirus used as a vector?

Adenoviruses are considered excellent vectors for delivering target antigens to mammalian hosts because of their capability to induce both innate and adaptive immune responses.

What is recombinant vesicular stomatitis virus?

Vesicular stomatitis virus (VSV) is a single-stranded negative-sense RNA virus in the family Rhabdoviridae. Although VSV can cause disease in livestock and other animals, it is highly restricted by the human IFN response and generally does not cause any or only very mild disease.

What is recombinant VSV?

Recombinant vesicular stomatitis virus (VSV) vectors are widely used for a variety of applications including studying mechanisms of viral entry into host cells, identification of cellular receptors utilized by viruses for cell entry, screening of viral entry inhibitors and vaccine development research.

Why are virus vectors used?

Viral vectors are tools commonly used by molecular biologists to deliver genetic material into cells. This process can be performed inside a living organism (in vivo) or in cell culture (in vitro). Viruses have evolved specialized molecular mechanisms to efficiently transport their genomes inside the cells they infect.

What is recombinant adenovirus vector?

Recombinant Adenovirus vectors have been extensively used to deliver foreign genes to a variety of cell types and tissues both in vitro and in vivo (1,2). They can be easily grown to high titer and can efficiently transfer genes into both dividing and non dividing cells.

Is there a vaccine for vesicular stomatitis?

The vesicular stomatitis virus (VSV) platform is a replication competent vaccine that has been shown to generate both cell-mediated and humoral immunity to expressed foreign antigens.

What is vesicular stomatitis virus vaccine?

Vesicular stomatitis virus (VSV) is a highly cytopathic virus being developed as a vaccine vector due to its ability to induce strong protective T cell and antibody responses after a single dose. However, little is known regarding the mechanisms underlying the potent immune responses elicited by VSV.

What does VSV stand for?

VSV

What is recombinant vector?

Recombinant vector vaccines are live replicating viruses that are engineered to carry extra genes derived from a pathogen—and these extra genes produce proteins against which we want to generate immunity.

How does the adenovirus vaccine work?

You get the vaccine, the adenovirus goes into your cell, it’s got this Trojan horse code on it that makes the spike protein. That spike protein then goes to the surface of your cell and then your immune system recognizes it and starts to make antibodies to it.