What protein does the MCM4 gene encode?

The MCM4 gene encodes the mini-chromosome maintenance complex member 4, which is part of the MCM2–7 complex. The MCM complex serves a helicase function to allow origin of recognition function in DNA replication.

What is MCM in DNA?

The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest checkpoints.

What is the function of MCM?

The MCM complex controls the once per cell cycle DNA replication in eukaryotic cells. In a process known as DNA replication licensing, it primes chromatin for DNA replication by binding origins of DNA replication during the late M to early G1 phase of the cell cycle.

What is MCM helicase?

The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint.

What is MCM loading?

Abstract. Loading of the MCM replicative helicase at origins of replication is a highly regulated process that precedes DNA replication in all eukaryotes. The stoichiometry of MCM loaded at origins has been proposed to be a key determinant of when those origins initiate replication during S phase.

What is CDC6 and Cdt1?

CDC6 is an ATP binding protein and a member of the pre-replicative complex (pre-RC) together with the origin recognition complex (ORC), Cdt1 and the MCM complex (containing MCM2-7p). CDC6 assembles after ORC in an ATP dependent manner and is required for loading MCM proteins onto the DNA.

What does Cdt1 stand for?

Abstract. Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis.

What are the 4 phases of mitosis and what happens in each?

1) Prophase: chromatin into chromosomes, the nuclear envelope break down, chromosomes attach to spindle fibres by their centromeres 2) Metaphase: chromosomes line up along the metaphase plate (centre of the cell) 3) Anaphase: sister chromatids are pulled to opposite poles of the cell 4) Telophase: nuclear envelope …

What is CDC6 and CDT1?

What does CDT1 do in cell cycle?

The CDT1 gene provides instructions for making a protein that is important in the copying of a cell’s DNA before the cell divides (a process known as DNA replication). The protein produced from this gene is one of a group of proteins known as the pre-replication complex.