Which of the following is a drug of low therapeutic index?
Table of Contents
- 1 Which of the following is a drug of low therapeutic index?
- 2 When a drug has a low therapeutic index that drug should be?
- 3 What drugs have a high therapeutic index?
- 4 Is digoxin a narrow therapeutic index?
- 5 Why some drugs have narrow therapeutic index?
- 6 What would be the most optimal drug to develop based on the therapeutic index?
Which of the following is a drug of low therapeutic index?
Drugs with a narrow therapeutic index 4 We defined the following drugs to be NTI-drugs: aminoglycosides, ciclosporin, carbamazepine, digoxin, digitoxin, flecainide, lithium, phenytoin, phenobarbital, rifampicin, theophylline and warfarin.
When a drug has a low therapeutic index that drug should be?
The larger the therapeutic index (TI), the safer the drug is. If the TI is small (the difference between the two concentrations is very small), the drug must be dosed carefully and the person receiving the drug should be monitored closely for any signs of drug toxicity.
What is a narrow therapeutic index drug?
Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What are therapeutic drugs and examples?
What is it used for?
| Types of Medicine | Medicine Names |
|---|---|
| Antibiotics | vancomycin, gentamycin, amakacin |
| Heart drugs | digoxin, procainamide, lidocaine |
| Anti-seizure drugs | phenytoin, phenobarbital |
| Drugs treat autoimmune diseases | cyclosporine, tacrolimus |
What drugs have a high therapeutic index?
examples include:
- warfarin.
- lithium.
- digoxin.
- phenytoin.
- gentamicin.
- amphotericin.
- 5-fluoro-urocil.
- zidovudine.
Is digoxin a narrow therapeutic index?
Digoxin has a narrow therapeutic index [1, 23, 25] so small variations in plasma concentration may readily result in toxic or sub therapeutic concentrations. Thus, consistency in bioavailability is important.
Why is high therapeutic preferable?
A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect.
What is therapeutic range of a drug?
The therapeutic range of a drug is the dosage range or blood plasma or serum concentration usually expected to achieve the desired therapeutic effect.
Why some drugs have narrow therapeutic index?
Some drugs have a narrow therapeutic index, which means that there is only a small difference between the minimum effective concentrations and the minimum toxic concentrations in the blood. With such drugs, small increases in dose or in blood/serum concentrations could lead to toxic effects.
What would be the most optimal drug to develop based on the therapeutic index?
A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect….Therapeutic index.
| Term | Meaning |
|---|---|
| TR | Therapeutic Ratio |
How many therapeutic drug classes are there?
Drug Class Codes: Codes used to identify each of 21 major therapeutic classes (and 139 subclasses) to which a drug may belong (adapted from Standard Drug Classifications in the National Drug Code (NDC) Directory, 1995).
What is a therapeutic drug index?
The therapeutic index (TI; also known as therapeutic ratio) is a ratio that compares the blood concentration at which a drug causes a therapeutic effect to the amount that causes death (in animal studies) or toxicity (in human studies) [1].